Arsenic Methyltransferase and Apolipoprotein E Polymorphism in Pregnant Women Exposed to Inorganic Arsenic in Drinking Water in Western Romania

被引:0
|
作者
Pop, Laura Ancuta [1 ]
Berindan-Neagoe, Ioana [1 ]
Bloom, Michael S. [2 ]
Neamtiu, Iulia Adina [3 ,4 ]
Bica, Cecilia [1 ]
Gurzau, Eugen S. [1 ]
机构
[1] Iuliu Hatieganu Univ Med & Pharm, Res Ctr Funct Genom Biomed & Translat Med, 8 Victor Babes St, Cluj Napoca 400012, Romania
[2] George Mason Univ, Dept Global & Community Hlth, 4400 Univ Dr, Fairfax, VA 22030 USA
[3] Environm Hlth Ctr Part ALS, Hlth Dept, 58 Busuiocului St, Cluj Napoca 400240, Romania
[4] Babes Bolyai Univ, Fac Environm Sci & Engn, 30 Fantanele St, Cluj Napoca 400294, Romania
关键词
inorganic arsenic; environmental exposure; genotyping; pregnancy; single-nucleotide polymorphism; MISCARRIAGE; METABOLISM; AS3MT; RISK; APOE; ASSOCIATION; VARIANTS; MERCURY; SMOKE; SEX;
D O I
10.3390/ijms25063349
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Previous studies have shown that inorganic arsenic (iAs) exposure may be associated with genotoxic and cytotoxic effects. The aim of this study was to evaluate the relationship between several polymorphisms in AS3MT and APOE genes and urinary As and the relationship between these polymorphisms and pregnancy loss. We determined urinary As concentrations and performed genotyping analysis in 50 cases of spontaneous pregnancy loss and 50 controls, matched to cases on gestational age. The most frequently identified AS3MT polymorphisms in both cases and controls were in rs10748835 (80% cases and 68% controls), rs3740400 (78% cases and 64% controls), rs7085104 (74% cases and 48% controls), and rs1046778 (62% cases and 54% controls). We identified 30 different haplotypes in AS3MT SNPs, with four predominant haplotypes (>8%). Cases with Haplotype 1 had four-fold higher urinary DMA and two-fold higher MMA concentration than those without this haplotype, the MMA levels were lower in cases and controls with Haplotype 4 compared to Haplotype 1, and the DMA levels were significantly lower in cases with Haplotype 4 compared to Haplotype 3. Cases with Haplotype 1 had higher levels of all analyzed biomarkers, suggesting that Haplotype 1 may be associated with greater exposure to iAs and tobacco smoke. Our results suggest the importance of the AS3MT gene in iAs metabolism among pregnant women with low-level drinking water iAs exposure.
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页数:13
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