Investigating the Antiviral Properties of Copper- and Silver-containing Polyoxometalates Using a High-throughput Screening Method

被引:1
|
作者
Yonesato, Kentaro [1 ]
Nakakido, Makoto [2 ,3 ]
Tsumoto, Kouhei [2 ,3 ,4 ]
Egami, Yuki [5 ]
Miyamae, Nobuhiro
Wakihara, Toru [6 ,7 ]
Suzuki, Kosuke [1 ]
Yamaguchi, Kazuya [1 ]
机构
[1] Univ Tokyo, Sch Engn, Dept Appl Chem, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1138656, Japan
[2] Univ Tokyo, Sch Engn, Dept Bioengn, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1138656, Japan
[3] Univ Tokyo, Sch Engn, Dept Chem & Biotechnol, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1138656, Japan
[4] Univ Tokyo, Inst Med Sci, 4-6-1 Shirokanedai,Minato Ku, Tokyo 1088639, Japan
[5] Nippon Paint Co Ltd, 4-1-15 Minamishinagawa,Shinagawa Ku, Tokyo 1408675, Japan
[6] Univ Tokyo, Sch Engn, Dept Chem Syst Engn, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1138656, Japan
[7] Univ Tokyo, Inst Engn Innovat, 2-11-16 Yayoi,Bunkyo Ku, Tokyo 1138656, Japan
关键词
Polyoxometalate; Antiviral materials; High-throughput screening; PHAGE DISPLAY; CATALYSIS; OXIDATION; MN; NI; CO; CU;
D O I
10.1246/cl.230264
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In this study, we investigated the antiviral properties of copper (Cu)-and silver (Ag)-containing polyoxometalates (POMs) using a high-throughput screening method based on a phagemid system using M13 filamentous phage. We found that the mono-Cu2+-containing POM supported on TiO2 exhibits high antiviral activity against M13 phage even with a low Cu amount. In contrast, there was no significant increase in the antiviral activity of the Ag-containing POMs supported on TiO2.
引用
收藏
页码:678 / 681
页数:4
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