Association between ABO blood group/genotype and COVID-19 in a Japanese population

被引：2

作者：

Kusumoto, Tatsuya ^{[1
]}

Chubachi, Shotaro ^{[1
]}

Namkoong, Ho ^{[2
]}

Tanaka, Hiromu ^{[1
]}

Lee, Ho ^{[1
]}

Azekawa, Shuhei ^{[1
]}

Otake, Shiro ^{[1
]}

Nakagawara, Kensuke ^{[1
]}

Fukushima, Takahiro ^{[1
]}

Morita, Atsuho ^{[1
]}

Watase, Mayuko ^{[3
]}

Sakurai, Kaori ^{[1
]}

Asakura, Takanori ^{[1
,4
]}

Masaki, Katsunori ^{[1
]}

Kamata, Hirofumi ^{[1
]}

Ishii, Makoto ^{[1
,5
]}

Hasegawa, Naoki ^{[2
]}

Harada, Norihiro ^{[6
,7
]}

Ueda, Tetsuya ^{[8
]}

Ueda, Soichiro ^{[9
]}

Ishiguro, Takashi ^{[10
]}

Arimura, Ken ^{[11
]}

Saito, Fukuki ^{[12
]}

Yoshiyama, Takashi ^{[13
]}

Nakano, Yasushi ^{[14
]}

Mutoh, Yoshikazu ^{[15
]}

Suzuki, Yusuke ^{[4
]}

Edahiro, Ryuya ^{[16
]}

Sano, Hirohito ^{[17
]}

Sato, Yasunori ^{[18
]}

Okada, Yukinori ^{[19
,20
,21
,22
,23
,24
]}

Koike, Ryuji ^{[25
]}

Kitagawa, Yuko ^{[26
]}

Tokunaga, Katsushi ^{[27
]}

Kimura, Akinori ^{[28
]}

Imoto, Seiya ^{[29
]}

Miyano, Satoru ^{[30
]}

Ogawa, Seishi ^{[31
,32
,33
]}

Kanai, Takanori ^{[34
]}

Fukunaga, Koichi ^{[1
]}

机构：

[1] Keio Univ, Dept Med, Div Pulm Med, Sch Med, 35 Shinanomachi,Shinjuku Ku, Tokyo 1608582, Japan

[2] Keio Univ, Dept Infect Dis, Sch Med, 35 Shinanomachi,Shinjuku Ku, Tokyo 1608582, Japan

[3] Natl Hosp Org Tokyo Med Ctr, Dept Resp Med, Tokyo, Japan

[4] Kitasato Univ, Dept Resp Med, Kitasato Inst Hosp, Tokyo, Japan

[5] Nagoya Univ, Dept Resp Med, Grad Sch Med, Nagoya, Japan

[6] Juntendo Univ, Fac Med, Dept Resp Med, Tokyo, Japan

[7] Juntendo Univ, Grad Sch Med, Dept Resp Med, Tokyo, Japan

[8] Osaka Saiseikai Nakatsu Hosp, Dept Resp Med, Osaka, Japan

[9] Saitama Med Ctr, Dept Internal Med, JCHO Japan Community Hlth Care Org, Saitama, Japan

[10] Saitama Cardiovasc & Resp Ctr, Dept Resp Med, Kumagaya, Japan

[11] Tokyo Womens Med Univ, Dept Resp Med, Tokyo, Japan

[12] Kansai Med Univ, Dept Emergency & Crit Care Med, Gen Med Ctr, Moriguchi, Japan

[13] Japan AntiTB Assoc, Fukujuji Hosp, Resp Dis Ctr, Tokyo, Japan

[14] Kawasaki Municipal Ida Hosp, Dept Internal Med, Kawasaki, Japan

[15] Tosei Gen Hosp, Dept Infect Dis, Seto, Japan

[16] Osaka Univ, Dept Resp Med & Clin Immunol, Grad Sch Med, Suita, Japan

[17] Tohoku Univ, Dept Resp Med, Grad Sch Med, Sendai, Japan

[18] Keio Univ, Dept Prevent Med & Publ Hlth, Sch Med, Tokyo, Japan

[19] Osaka Univ, Dept Stat Genet, Grad Sch Med, Suita, Japan

[20] Osaka Univ, Inst Open & Transdisciplinary Res Initiat, Integrated Frontier Res Med Sci Div, Suita, Japan

[21] Osaka Univ, Ctr Infect Dis Educ & Res CiDER, Suita, Japan

[22] Osaka Univ, Immunol Frontier Res Ctr WPI IFReC, Lab Stat Immunol, Suita, Japan

[23] Univ Tokyo, Grad Sch Med, Dept Genome Informat, Tokyo, Japan

[24] RIKEN Ctr Integrat Med Sci, Lab Syst Genet, Yokohama, Kanagawa, Japan

[25] Tokyo Med & Dent Univ, Med Innovat Promot Ctr, Tokyo, Japan

[26] Keio Univ, Dept Surg, Sch Med, Tokyo, Japan

[27] Natl Ctr Global Hlth & Med, Genome Med Sci Project Toyama, Tokyo, Japan

[28] Tokyo Med & Dent Univ, Inst Res, Tokyo, Japan

[29] Univ Tokyo, Inst Med Sci, Human Genome Ctr, Div Hlth Med Intelligence, Tokyo, Japan

[30] Tokyo Med & Dent Univ, M&D Data Sci Ctr, Tokyo, Japan

[31] Kyoto Univ, Dept Pathol & Tumor Biol, Kyoto, Japan

[32] Kyoto Univ, Inst Adv Study Human Biol WPI ASHBi, Kyoto, Japan

[33] Karolinska Inst, Ctr Hematol & Regenerat Med, Dept Med, Stockholm, Sweden

[34] Keio Univ, Dept Med, Div Gastroenterol & Hepatol, Sch Med, Tokyo, Japan

来源：

ANNALS OF HEMATOLOGY | 2023年 / 102卷 / 11期

关键词：

COVID-19; ABO blood group; ABO genotype; Japanese population; RISK; SUSCEPTIBILITY; INFECTION; CANCER;

D O I：

10.1007/s00277-023-05407-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An association between coronavirus disease 2019 (COVID-19) and the ABO blood group has been reported. However, such an association has not been studied in the Japanese population on a large scale. Little is known about the association between COVID-19 and ABO genotype. This study investigated the association between COVID-19 and ABO blood group/genotype in a large Japanese population. All Japanese patients diagnosed with COVID-19 were recruited through the Japan COVID-19 Task Force between February 2020 and October 2021. We conducted a retrospective cohort study involving 1790 Japanese COVID-19 patients whose DNA was used for a genome-wide association study. We compared the ABO blood group/genotype in a healthy population (n = 611, control) and COVID-19 patients and then analyzed their associations and clinical outcomes. Blood group A was significantly more prevalent (41.6% vs. 36.8%; P = 0.038), and group O was significantly less prevalent (26.2% vs. 30.8%; P = 0.028) in the COVID-19 group than in the control group. Moreover, genotype OO was significantly less common in the COVID-19 group. Furthermore, blood group AB was identified as an independent risk factor for most severe diseases compared with blood group O [aOR (95% CI) = 1.84 (1.00-3.37)]. In ABO genotype analysis, only genotype AB was an independent risk factor for most severe diseases compared with genotype OO. Blood group O is protective, whereas group A is associated with the risk of infection. Moreover, blood group AB is associated with the risk of the "most" severe disease.

引用

页码：3239 / 3249

页数：11

共 50 条

[1] Association between ABO blood group/genotype and COVID-19 in a Japanese population
Tatsuya Kusumoto
Shotaro Chubachi
Ho Namkoong
Hiromu Tanaka
Ho Lee
Shuhei Azekawa
Shiro Otake
Kensuke Nakagawara
Takahiro Fukushima
Atsuho Morita
Mayuko Watase
Kaori Sakurai
Takanori Asakura
Katsunori Masaki
Hirofumi Kamata
Makoto Ishii
Naoki Hasegawa
Norihiro Harada
Tetsuya Ueda
Soichiro Ueda
Takashi Ishiguro
Ken Arimura
Fukuki Saito
Takashi Yoshiyama
Yasushi Nakano
Yoshikazu Mutoh
Yusuke Suzuki
Ryuya Edahiro
Hirohito Sano
Yasunori Sato
Yukinori Okada
Ryuji Koike
Yuko Kitagawa
Katsushi Tokunaga
Akinori Kimura
Seiya Imoto
Satoru Miyano
Seishi Ogawa
Takanori Kanai
Koichi Fukunaga
[J]. Annals of Hematology, 2023, 102 : 3239 - 3249
[2] On the association between the ABO blood group and COVID-19 susceptibility
Golinelli, Davide
[J]. BLOOD TRANSFUSION, 2021, 19 (01) : 89 - 90
[3] ABO Blood Group Association With COVID-19 Mortality
Akhlaq, Hira
Tizro, Parastou
Aggarwal, Anita
Nava, Victor E.
[J]. JOURNAL OF HEMATOLOGY, 2022, 11 (03) : 121 - 122
[4] Association Between ABO Blood Group System and COVID-19 Susceptibility in Wuhan
Fan, Qian
Zhang, Wei
Li, Bo
Li, De-Jia
Zhang, Jian
Zhao, Fang
[J]. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2020, 10
[5] A population-based, retrospective cohort study of the association between ABO blood group and risk of COVID-19
Dahlen, Torsten
Li, Huiqi
Nyberg, Fredrik
Edgren, Gustaf
[J]. JOURNAL OF INTERNAL MEDICINE, 2023, 293 (03) : 398 - 402
[6] Potential association of COVID-19 and ABO blood group: An Indian study
Garg, Iti
Srivastava, Swati
Dogra, Vikas
Bargotya, Mona
Bhattar, Sonali
Gupta, Utkarsh
Jain, Shruti
Hussain, Javid
Hembrom, Anju A.
Ghosh, Nilanjana
Kumar, Vinay
Kumar, Bhuvnesh
Varshney, Rajeev
Ganju, Lilly
[J]. MICROBIAL PATHOGENESIS, 2021, 158
[7] Association of ABO blood group type with cardiovascular events in COVID-19
Victor Nauffal
Aditya Achanta
Samuel Z. Goldhaber
Gregory Piazza
[J]. Journal of Thrombosis and Thrombolysis, 2021, 51 : 584 - 586
[8] Association of ABO blood group and age with COVID-19 positive test
Nalbant, Ahmet
Aydin, Ayhan
Yaylaci, Selcuk
Kaya, Tezcan
Wermeulen, Charlotte Lynn
Cinemre, Hakan
[J]. REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, 2021, 67 : 46 - 50
[9] The association of ABO blood group with the asymptomatic COVID-19 cases in India
Singh, Prajjval Pratap
Srivastava, Abhishek K.
Upadhyay, Sudhir K.
Singh, Ashish
Upadhyay, Shashank
Kumar, Pradeep
Rai, Vandana
Shrivastava, Pankaj
Chaubey, Gyaneshwer
[J]. TRANSFUSION AND APHERESIS SCIENCE, 2021, 60 (06)
[10] Association of ABO blood group type with cardiovascular events in COVID-19
Nauffal, Victor
Achanta, Aditya
Goldhaber, Samuel Z.
Piazza, Gregory
[J]. JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 2021, 51 (03) : 584 - 586

← 1 2 3 4 5 →