Proposing of SPR biosensor based on 2D Ti3C2Tx MXene for uric acid detection immobilized by uricase enzyme

This paper proposes a surface plasmon resonance (SPR) biosensor based on Ti3C2Tx MXene two-dimensional material to detect uric acid by utilizing urate oxidase enzyme. The proposed biosensor is a free space structure using Kretschmann configuration to stimulate the surface plasmons. The structure consists of SF11 prism, BK7 glass, silver (Ag), tungsten disulfide (WS2), graphene, Ti3C2Tx MXene, and the sensing medium. The minimum reflection, sensitivity, figure of merit, and detection accuracy of the SPR are investigated using the numerical method of FDTD in the visible region. Molarity varies from 0 to 500 ppm and refractive index from 1.3300 to 1.3336 for the sensing layer. The results indicate that the highest sensitivity of 273.53 deg/RIU can be achieved with a thickness of 50 nm Ag and a monolayer of WS2, a monolayer of graphene, and four layers of Ti3C2Tx MXene, at 633 nm wavelength.