Current perspectives on fecal microbiota transplantation in inflammatory bowel disease

被引:5
|
作者
Singh, Arshdeep [1 ]
Midha, Vandana [2 ]
Chauhan, Nar Singh [3 ]
Sood, Ajit [1 ]
机构
[1] Dayanand Med Coll & Hosp, Dept Gastroenterol, Ludhiana 141001, India
[2] Dayanand Med Coll & Hosp, Dept Internal Med, Ludhiana 141001, India
[3] Maharshi Dayanand Univ, Dept Biochem, Rohtak, India
关键词
Donor selection; Dysbiosis; Fecal microbiota transplantation; Gastrointestinal microbiome; Inflammatory bowel disease; Ulcerative colitis; CLOSTRIDIUM-DIFFICILE INFECTION; ACTIVE ULCERATIVE-COLITIS; GUT MICROBIOTA; TREATING PATIENTS; EFFICACY; RECURRENT; DONORS; FROZEN; REMISSION; INSIGHTS;
D O I
10.1007/s12664-023-01516-8
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Fecal microbiota transplantation (FMT) has emerged as a promising therapeutic modality within the domain of inflammatory bowel disease (IBD). While FMT has secured approval and demonstrated efficacy in addressing recurrent and refractory Clostridioides difficile infection, its application in IBD remains an area of active exploration and research. The current status of FMT in IBD reflects a nuanced landscape, with ongoing investigations delving into its effectiveness, safety and optimal implementation. Early-stage clinical trials and observational studies have provided insights into the potential of FMT to modulate the dysbiotic gut microbiota associated with IBD, aiming to mitigate inflammation and promote mucosal healing. However, considerable complexities persist, including variations in donor selection, treatment protocols and outcome assessments. Challenges in standardizing FMT protocols for IBD treatment are compounded by the dynamic nature of the gut microbiome and the heterogeneity of IBD itself. Despite these challenges, enthusiasm for FMT in IBD emanates from its capacity to address gut microbial dysbiosis, signifying a paradigm shift towards more comprehensive approaches in IBD management. As ongoing research progresses, an enhanced understanding of FMT's role in IBD therapy is anticipated. This article synthesizes the current status of FMT in IBD, elucidating the attendant challenges and aspiring towards the refinement of its application for improved patient outcomes.
引用
收藏
页码:129 / 144
页数:16
相关论文
共 50 条
  • [1] Current perspectives on fecal microbiota transplantation in inflammatory bowel disease
    Arshdeep Singh
    Vandana Midha
    Nar Singh Chauhan
    Ajit Sood
    Indian Journal of Gastroenterology, 2024, 43 : 129 - 144
  • [2] Fecal Microbiota Transplantation in Inflammatory Bowel Disease
    Reinisch, Walter
    DIGESTIVE DISEASES, 2017, 35 (1-2) : 123 - 126
  • [3] Fecal Microbiota Transplantation in Inflammatory Bowel Disease
    Boicean, Adrian
    Birlutiu, Victoria
    Ichim, Cristian
    Anderco, Paula
    Birsan, Sabrina
    BIOMEDICINES, 2023, 11 (04)
  • [4] Intestinal microbiota, fecal microbiota transplantation, and inflammatory bowel disease
    Weingarden, Alexa R.
    Vaughn, Byron P.
    GUT MICROBES, 2017, 8 (03) : 238 - 252
  • [5] Role of fecal microbiota transplantation in inflammatory bowel disease
    D'Odorico, Irene
    Di Bella, Stefano
    Monticelli, Jacopo
    Giacobbe, Daniele R.
    Boldock, Emma
    Luzzati, Roberto
    JOURNAL OF DIGESTIVE DISEASES, 2018, 19 (06) : 322 - 334
  • [6] Intestinal microbiota pathogenesis and fecal microbiota transplantation for inflammatory bowel disease
    Zi-Kai Wang
    Yun-Sheng Yang
    Ye Chen
    Jing Yuan
    Gang Sun
    Li-Hua Peng
    World Journal of Gastroenterology, 2014, (40) : 14805 - 14820
  • [7] Intestinal microbiota pathogenesis and fecal microbiota transplantation for inflammatory bowel disease
    Wang, Zi-Kai
    Yang, Yun-Sheng
    Chen, Ye
    Yuan, Jing
    Sun, Gang
    Peng, Li-Hua
    WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (40) : 14805 - 14820
  • [8] Autologous fecal microbiota transplantation for the treatment of inflammatory bowel disease
    Basson, Abigail R.
    Zhou, Yibing
    Seo, Brian
    Rodriguez-Palacios, Alexander
    Cominelli, Fabio
    TRANSLATIONAL RESEARCH, 2020, 226 : 1 - 11
  • [9] The Role of Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease
    Stojek, Magdalena
    Jablonska, Anna
    Adrych, Krystian
    JOURNAL OF CLINICAL MEDICINE, 2021, 10 (18)
  • [10] Fecal Microbiota Transplantation in Inflammatory Bowel Disease: Beyond the Excitement
    Ianiro, Gianluca
    Bibbo, Stefano
    Scaldaferri, Franco
    Gasbarrini, Antonio
    Cammarota, Giovanni
    MEDICINE, 2014, 93 (19)