Fecal microbiota transplantation (FMT) has emerged as a promising therapeutic modality within the domain of inflammatory bowel disease (IBD). While FMT has secured approval and demonstrated efficacy in addressing recurrent and refractory Clostridioides difficile infection, its application in IBD remains an area of active exploration and research. The current status of FMT in IBD reflects a nuanced landscape, with ongoing investigations delving into its effectiveness, safety and optimal implementation. Early-stage clinical trials and observational studies have provided insights into the potential of FMT to modulate the dysbiotic gut microbiota associated with IBD, aiming to mitigate inflammation and promote mucosal healing. However, considerable complexities persist, including variations in donor selection, treatment protocols and outcome assessments. Challenges in standardizing FMT protocols for IBD treatment are compounded by the dynamic nature of the gut microbiome and the heterogeneity of IBD itself. Despite these challenges, enthusiasm for FMT in IBD emanates from its capacity to address gut microbial dysbiosis, signifying a paradigm shift towards more comprehensive approaches in IBD management. As ongoing research progresses, an enhanced understanding of FMT's role in IBD therapy is anticipated. This article synthesizes the current status of FMT in IBD, elucidating the attendant challenges and aspiring towards the refinement of its application for improved patient outcomes.
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McMaster Univ, Div Gastroenterol, Dept Internal Med, 1280 Main St West, Hamilton, ON L85 4K1, CanadaMcMaster Univ, Div Gastroenterol, Dept Internal Med, 1280 Main St West, Hamilton, ON L85 4K1, Canada
机构:
Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Chinese PLA Medical AcademyDepartment of Gastroenterology and Hepatology, Chinese PLA General Hospital, Chinese PLA Medical Academy
Zi-Kai Wang
Yun-Sheng Yang
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Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Chinese PLA Medical AcademyDepartment of Gastroenterology and Hepatology, Chinese PLA General Hospital, Chinese PLA Medical Academy
Yun-Sheng Yang
Ye Chen
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Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangdong Provincial Key Labo-ratory of GastroenterologyDepartment of Gastroenterology and Hepatology, Chinese PLA General Hospital, Chinese PLA Medical Academy
Ye Chen
Jing Yuan
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Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing 100071, ChinaDepartment of Gastroenterology and Hepatology, Chinese PLA General Hospital, Chinese PLA Medical Academy
Jing Yuan
Gang Sun
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Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Chinese PLA Medical AcademyDepartment of Gastroenterology and Hepatology, Chinese PLA General Hospital, Chinese PLA Medical Academy
Gang Sun
Li-Hua Peng
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Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Chinese PLA Medical AcademyDepartment of Gastroenterology and Hepatology, Chinese PLA General Hospital, Chinese PLA Medical Academy
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Chinese PLA Med Acad, Chinese PLA Gen Hosp, Dept Gastroenterol & Hepatol, Beijing 100853, Peoples R ChinaChinese PLA Med Acad, Chinese PLA Gen Hosp, Dept Gastroenterol & Hepatol, Beijing 100853, Peoples R China
Wang, Zi-Kai
Yang, Yun-Sheng
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Chinese PLA Med Acad, Chinese PLA Gen Hosp, Dept Gastroenterol & Hepatol, Beijing 100853, Peoples R ChinaChinese PLA Med Acad, Chinese PLA Gen Hosp, Dept Gastroenterol & Hepatol, Beijing 100853, Peoples R China
Yang, Yun-Sheng
Chen, Ye
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Southern Med Univ, Nanfang Hosp, Dept Gastroenterol, Guangdong Prov Key Lab Gastroenterol, Guangzhou 510515, Guangdong, Peoples R ChinaChinese PLA Med Acad, Chinese PLA Gen Hosp, Dept Gastroenterol & Hepatol, Beijing 100853, Peoples R China
Chen, Ye
Yuan, Jing
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Acad Mil Med Sci, Inst Dis Control & Prevent, Beijing 100071, Peoples R ChinaChinese PLA Med Acad, Chinese PLA Gen Hosp, Dept Gastroenterol & Hepatol, Beijing 100853, Peoples R China
Yuan, Jing
Sun, Gang
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Chinese PLA Med Acad, Chinese PLA Gen Hosp, Dept Gastroenterol & Hepatol, Beijing 100853, Peoples R ChinaChinese PLA Med Acad, Chinese PLA Gen Hosp, Dept Gastroenterol & Hepatol, Beijing 100853, Peoples R China
Sun, Gang
Peng, Li-Hua
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Chinese PLA Med Acad, Chinese PLA Gen Hosp, Dept Gastroenterol & Hepatol, Beijing 100853, Peoples R ChinaChinese PLA Med Acad, Chinese PLA Gen Hosp, Dept Gastroenterol & Hepatol, Beijing 100853, Peoples R China
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A Gemelli Univ Hosp, Div Internal Med & Gastroenterol, I-00168 Rome, Italy
A Gemelli Univ Hosp, Dept Med Sci, Div Internal Med & Gastroenterol, I-00168 Rome, ItalyA Gemelli Univ Hosp, Div Internal Med & Gastroenterol, I-00168 Rome, Italy
Ianiro, Gianluca
Bibbo, Stefano
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A Gemelli Univ Hosp, Div Internal Med & Gastroenterol, I-00168 Rome, Italy
A Gemelli Univ Hosp, Dept Med Sci, Div Internal Med & Gastroenterol, I-00168 Rome, ItalyA Gemelli Univ Hosp, Div Internal Med & Gastroenterol, I-00168 Rome, Italy
Bibbo, Stefano
Scaldaferri, Franco
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A Gemelli Univ Hosp, Div Internal Med & Gastroenterol, I-00168 Rome, Italy
A Gemelli Univ Hosp, Dept Med Sci, Div Internal Med & Gastroenterol, I-00168 Rome, ItalyA Gemelli Univ Hosp, Div Internal Med & Gastroenterol, I-00168 Rome, Italy
Scaldaferri, Franco
Gasbarrini, Antonio
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A Gemelli Univ Hosp, Div Internal Med & Gastroenterol, I-00168 Rome, Italy
A Gemelli Univ Hosp, Dept Med Sci, Div Internal Med & Gastroenterol, I-00168 Rome, ItalyA Gemelli Univ Hosp, Div Internal Med & Gastroenterol, I-00168 Rome, Italy
Gasbarrini, Antonio
Cammarota, Giovanni
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A Gemelli Univ Hosp, Div Internal Med & Gastroenterol, I-00168 Rome, Italy
A Gemelli Univ Hosp, Dept Med Sci, Div Internal Med & Gastroenterol, I-00168 Rome, ItalyA Gemelli Univ Hosp, Div Internal Med & Gastroenterol, I-00168 Rome, Italy