Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction

被引：10

作者：

Rabaan, Ali A. ^{[1
,2
,3
]}

AlSaihati, Hajir ^{[4
]}

Bukhamsin, Rehab ^{[5
]}

Bakhrebah, Muhammed A. ^{[6
]}

Nassar, Majed S. ^{[6
]}

Alsaleh, Abdulmonem A. ^{[7
]}

Alhashem, Yousef N. ^{[7
]}

Bukhamseen, Ammar Y. ^{[8
]}

Al-Ruhimy, Khalil ^{[9
]}

Alotaibi, Mohammed ^{[9
]}

Alsubki, Roua A. ^{[10
]}

Alahmed, Hejji E. ^{[11
]}

Al-Abdulhadi, Saleh ^{[12
,13
]}

Alhashem, Fatemah A. ^{[14
]}

Alqatari, Ahlam A. ^{[15
]}

Alsayyah, Ahmed ^{[16
]}

Farahat, Ramadan Abdelmoez ^{[17
]}

Abdulal, Rwaa H. ^{[18
,19
]}

Al-Ahmed, Ali H. ^{[20
]}

Imran, Mohd. ^{[21
]}

Mohapatra, Ranjan K. ^{[22
]}

机构：

[1] Johns Hopkins Aramco Healthcare, Mol Diagnost Lab, Dhahran 31311, Saudi Arabia

[2] Alfaisal Univ, Coll Med, Riyadh 11533, Saudi Arabia

[3] Univ Haripur, Dept Publ Hlth & Nutr, Haripur 22610, Pakistan

[4] Univ Hafr Al Batin, Coll Appl Med Sci, Dept Clin Lab Sci, Hafar al Batin 39831, Saudi Arabia

[5] Dammam Reg Lab & Blood Bank, Dammam 31411, Saudi Arabia

[6] King Abdulaziz City Sci & Technol KACST, Life Sci & Environm Res Inst, Riyadh 11442, Saudi Arabia

[7] Mohammed Al Mana Coll Med Sci, Clin Lab Sci Dept, Dammam 34222, Saudi Arabia

[8] Imam Abdulrahman Bin Faisal Univ, Coll Med, Dept Internal Med, Dammam 34212, Saudi Arabia

[9] Minist Hlth, Dept Publ Hlth, Riyadh 14235, Saudi Arabia

[10] King Saud Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Riyadh 11362, Saudi Arabia

[11] King Fahad Hosp, Dept Lab & Blood Bank, Al Hufuf 36441, Saudi Arabia

[12] Prince Sattam Bin Abdulaziz Univ, Coll Appl Med Sci, Dept Med Lab Sci, Riyadh 11942, Saudi Arabia

[13] Prince Sattam Bin Abdulaziz Univ, Saleh Off Med Genet & Genet Counseling Serv, House Expertise, Dammam 32411, Saudi Arabia

[14] King Fahad Hosp Univ, Lab Med Dept, Hematopathol Div, Al Khobar 31441, Saudi Arabia

[15] Al Dorr Specialist Med Ctr, Hematopathol Dept, Clin Pathol, Qatif 31911, Saudi Arabia

[16] Imam Abdulrahman Bin Faisal Univ, Coll Med, Dept Pathol, Dammam 31441, Saudi Arabia

[17] Kafrelsheikh Univ, Fac Med, Kafr El Shaikh 33511, Egypt

[18] King Abdulaziz Univ, Fac Sci, Dept Biol, Jeddah 21589, Saudi Arabia

[19] King Abdulaziz Univ, King Fahad Med Res Ctr, Vaccines & Immunotherapy Unit, Jeddah 21589, Saudi Arabia

[20] Eastern Hlth Cluster, Dammam Hlth Network, Dammam 31444, Saudi Arabia

[21] Northern Border Univ, Fac Pharm, Dept Pharmaceut Chem, Rafha 91911, Saudi Arabia

[22] Govt Coll Engn, Dept Chem, Keonjhar 758002, India

来源：

CURRENT ONCOLOGY | 2023年 / 30卷 / 02期

关键词：

CRISPR; Cas; advanced technologies; advanced therapeutics; cancer; cancer treatment; oncoviruses; clinical trials; HUMAN HEMATOPOIETIC STEM; GENOME-EDITING TOOL; ADAPTIVE IMMUNITY; BLADDER-CANCER; GENE-THERAPY; GUIDE-RNA; CRISPR-CAS9; CELLS; ZFNS; EPIGENOME;

D O I：

10.3390/curroncol30020152

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gene editing, especially with clustered regularly interspaced short palindromic repeats associated protein 9 (CRISPR-Cas9), has advanced gene function science. Gene editing's rapid advancement has increased its medical/clinical value. Due to its great specificity and efficiency, CRISPR/Cas9 can accurately and swiftly screen the whole genome. This simplifies disease-specific gene therapy. To study tumor origins, development, and metastasis, CRISPR/Cas9 can change genomes. In recent years, tumor treatment research has increasingly employed this method. CRISPR/Cas9 can treat cancer by removing genes or correcting mutations. Numerous preliminary tumor treatment studies have been conducted in relevant fields. CRISPR/Cas9 may treat gene-level tumors. CRISPR/Cas9-based personalized and targeted medicines may shape tumor treatment. This review examines CRISPR/Cas9 for tumor therapy research, which will be helpful in providing references for future studies on the pathogenesis of malignancy and its treatment.

引用

页码：1954 / 1976

页数：23

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