Convergence of Visual and Motor Awareness in Human Parietal Cortex

被引:1
|
作者
Monai, Elena [1 ]
Pini, Lorenzo [2 ]
Palacino, Federica [1 ,3 ]
Bisio, Marta [4 ]
Bernocchi, Francesca [1 ,5 ]
Salvalaggio, Alessandro [1 ,2 ]
Corbetta, Maurizio [1 ,2 ,6 ]
机构
[1] Univ Padua, Dept Neurosci, Neurol Clin, Padua, Italy
[2] Univ Padua, Padua Neurosci Ctr, Via Giustiniani 2, I-35128 Padua, Italy
[3] Univ Trieste, Neurol Clin, Trieste, Italy
[4] Univ Padua, Dept Informat Engn, Padua, Italy
[5] Univ Rome, Tor Vergata Neurol Clin, Rome, Italy
[6] Venetian Inst Mol Med, Padua, Italy
基金
欧盟地平线“2020”; 欧洲研究理事会;
关键词
ANTONS-SYNDROME; BRAIN; ANOSOGNOSIA; LESIONS; ATTENTION; SYMPTOMS; ANATOMY;
D O I
10.1002/ana.26791
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: Brain lesions sometimes induce a failure of recognition of one's own deficits (anosognosia). Lack of deficit awareness may underlie damage of modality-specific systems, for example, visual cortex for visual anosognosia or motor/premotor cortex for motor anosognosia. However, focal lesions induce widespread remote structural and functional disconnection, and anosognosia, independent of modality, may also involve common neural mechanisms. Methods: Here, we study the neural correlates of Anton syndrome (AS), anosognosia of blindness, and compare them with anosognosia for hemiplegia to test whether they share different or common mechanisms. We measured both local damage and patterns of structural-functional disconnection as predicted from healthy normative atlases. Results: AS depends on bilateral striate and extrastriate occipital damage, and disconnection of ventral and dorsal frontoparietal regions involved in attention control. Visual and motor anosognosia each share damage of modality-specific regions, but also involve the disruption of white matter tracts, leading to functional disconnection within dorsal frontal-parietal regions that play critical roles in motor control, visuospatial attention, and multisensory integration. Interpretation: These results reveal the unique shared combination of content-specific and supramodal mechanisms in anosognosia.
引用
收藏
页码:90 / 103
页数:14
相关论文
共 50 条
  • [1] Human visual and parietal cortex encode visual choices independent of motor plans
    Hebart, Martin N.
    Donner, Tobias H.
    Haynes, John-Dylan
    [J]. NEUROIMAGE, 2012, 63 (03) : 1393 - 1403
  • [2] Modulation of excitatory and inhibitory circuits for visual awareness in the human right parietal cortex
    Koch, G
    Oliveri, M
    Torriero, S
    Caltagirone, C
    [J]. EXPERIMENTAL BRAIN RESEARCH, 2005, 160 (04) : 510 - 516
  • [3] Modulation of excitatory and inhibitory circuits for visual awareness in the human right parietal cortex
    Giacomo Koch
    Massimiliano Oliveri
    Sara Torriero
    Carlo Caltagirone
    [J]. Experimental Brain Research, 2005, 160 : 510 - 516
  • [4] Visual grouping in human parietal cortex
    Xu, Yaoda
    Chun, Marvin M.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (47) : 18766 - 18771
  • [5] Sensory-motor mechanisms in human parietal cortex underlie arbitrary visual decisions
    Tosoni, Annalisa
    Galati, Gaspare
    Romani, Gian Luca
    Corbetta, Maurizio
    [J]. NATURE NEUROSCIENCE, 2008, 11 (12) : 1446 - 1453
  • [6] Sensory-motor mechanisms in human parietal cortex underlie arbitrary visual decisions
    Annalisa Tosoni
    Gaspare Galati
    Gian Luca Romani
    Maurizio Corbetta
    [J]. Nature Neuroscience, 2008, 11 : 1446 - 1453
  • [7] Dissociation of visual, motor and predictive signals in parietal cortex during visual guidance
    Eskandar, EN
    Assad, JA
    [J]. NATURE NEUROSCIENCE, 1999, 2 (01) : 88 - 93
  • [8] Dissociation of visual, motor and predictive signals in parietal cortex during visual guidance
    Emad N. Eskandar
    John A. Assad
    [J]. Nature Neuroscience, 1999, 2 : 88 - 93
  • [9] Selective recruitment of motor cortex and parietal cortex during visual perception of biologically possible apparent human movements.
    Stevens, JA
    Fonlupt, P
    Shiffrar, M
    Decety, J
    [J]. JOURNAL OF COGNITIVE NEUROSCIENCE, 1999, : 86 - 86
  • [10] Maintenance of visual stability in the human posterior parietal cortex
    Chang, Erik
    Ro, Tony
    [J]. JOURNAL OF COGNITIVE NEUROSCIENCE, 2007, 19 (02) : 266 - 274