Synthesis of photostable near-infrared sulfone-rhodamines for photoacoustic imaging-guided photothermal therapy

被引:4
|
作者
Si, Huiyu [1 ]
Wang, Dongjuan [1 ]
Du, Xianfa [2 ]
Zhou, Xin [1 ]
机构
[1] Qingdao Univ, Coll Chem & Chem Engn, Dept Chem, Qingdao 266071, Peoples R China
[2] Qingdao Univ, Dept Orthoped, Affiliated Hosp, Qingdao 266071, Peoples R China
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
Photothermal therapy; Sulfone rhodamine; Near-Infrared; Photoacoustic; Imaging; DYES;
D O I
10.1016/j.cclet.2023.108595
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Photothermal therapy (PTT) is a cutting-edge cancer treatment that can kill cancer cells in hypoxic environments without relying on oxygen. Seeking of the ideal photothermal agents with a high absorption coefficient in the near-infrared region, and a high excellent photothermal conversion efficiency is of great significance. Sulfone-Rhodanmine dye has showed an impressive absorption wavelength over 700 nm, but suffered from a stability issue. In this study, we synthesized five sulfone rhodamines and investigated the substitution effects on stability. SO2R2 showed high stability and strong absorbance at 714 nm with an excellent photothermal conversion efficiency of 53.06%, making it suitable for accurate photoacoustic imaging-guided photothermal therapy in vivo .(c) 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
引用
收藏
页数:4
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