FMMAS-OCT: Aberration correction for high-resolution cellular imaging

被引：1

作者：

Ge, Xin ^{[1
]}

He, Jin ^{[1
]}

Chen, Si ^{[2
]}

Ni, Guangming ^{[3
]}

Xiong, Qiaozhou ^{[4
]}

Yang, Jielong ^{[5
]}

Yu, Lequan ^{[6
]}

Liu, Linbo ^{[2
,7
,8
]}

Bo, En ^{[2
,9
]}

机构：

[1] Sun Yat sen Univ, Sch Sci, Shenzhen Campus, Shenzhen 518107, Peoples R China

[2] Nanyang Technol Univ, Sch Elect & Elect Engn, Singapore 639798, Singapore

[3] Univ Elect Sci & Technol China, Sch Optoelect Sci & Engn, Chengdu 610054, Peoples R China

[4] InnerMed Co Ltd, Shenzhen 518055, Peoples R China

[5] Jiangnan Univ, Sch Internet Things Engn, Wuxi 214122, Peoples R China

[6] Univ Hong Kong, Dept Stat & Actuarial Sci, Hong Kong 999077, Peoples R China

[7] Nanyang Technol Univ, Sch Chem & Biomed Engn, Singapore 637459, Singapore

[8] China Singapore Int Joint Res Inst CSIJRI, Guangzhou 510000, Peoples R China

[9] GeneMind Biosci Co Ltd, Shenzhen 518023, Peoples R China

来源：

OPTICS AND LASERS IN ENGINEERING | 2024年 / 174卷

基金：

英国医学研究理事会;

关键词：

High resolution; Optical coherence tomography; Forward model; Multiple aperture synthesis; OPTICAL COHERENCE TOMOGRAPHY; ADAPTIVE-OPTICS; INTERFEROMETRIC TOMOGRAPHY; FOCUS-EXTENSION; APERTURE;

D O I：

10.1016/j.optlaseng.2023.107964

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

In optical coherence tomography (OCT), spatial resolution and signal strength often suffer due to aberrations from both the imaging system and the sample. In this work, we introduce a novel method, FMMAS (ForwardModel Multiple Aperture Synthesis), which effectively compensates for these aberrations. It combines forwardmodel (FM) based method for transverse resolution restoration and multiple aperture synthesis (MAS) to mitigate depth domain aberrations. Our proof-of-concept experiment demonstrates a significant improvement in the mean transverse full width at half maximum (FWHM) of microparticles by 46.1 %. Compared to original OCT and FM method, FMMAS produces sharper, 'pencil beam'-like imaging, resolving cell nuclei in swine esophagus ex vivo and human blood cells in vivo, suggesting a potential for significant enhancements in OCT image quality.

引用

页数：8

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