Genomic insights into heart health: Exploring the genetic basis of cardiovascular disease

被引:5
|
作者
Safdar, Mishal [1 ]
Ullah, Muneeb [2 ]
Wahab, Abdul [2 ]
Hamayun, Shah [3 ]
Rehman, Mahboob Ur [3 ]
Khan, Muhammad Amir [4 ]
Khan, Shahid Ullah [5 ]
Ullah, Aziz [6 ]
Din, Fakhar Ud [7 ]
Awan, Uzma Azeem [1 ]
Naeem, Muhammad [1 ]
机构
[1] Natl Univ Med Sci NUMS Rawalpindi, Dept Biol Sci, Punjab 46000, Pakistan
[2] Kohat Univ Sci & technol KUST, Dept Pharm, Kohat 26000, Khyber Pakhtunk, Pakistan
[3] Pakistan Inst Med PIMS, Dept Cardiol, Islamabad 04485, Punjab, Pakistan
[4] Fergana Med Inst Publ Hlth, Dept Foreign Med Educ, 2A Yangi Turon St, Fergana 150100, Uzbekistan
[5] Khyber Med Univ, Women Med & Dent Coll, Dept Biochem, Abbottabad 22080, Khyber Pakhtunk, Pakistan
[6] Pukyong Natl Univ, Dept Chem Engn, Busan 48513, South Korea
[7] Quaid I Azam Univ, Dept Pharm, Islamabad 45320, Pakistan
关键词
Genetics; CVD; Nanotechnology; Nanoparticles; Heart diseases; CORONARY-ARTERY-BYPASS; MYOCARDIAL-INFARCTION; HYPERTROPHIC CARDIOMYOPATHY; ENVIRONMENT INTERACTION; ATRIAL-FIBRILLATION; CELL THERAPY; RISK-FACTORS; NANOTECHNOLOGY; PREVENTION; MUTATIONS;
D O I
10.1016/j.cpcardiol.2023.102182
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Cardiovascular diseases (CVDs) are considered as the leading cause of death worldwide. CVD continues to be a major cause of death and morbidity despite significant improvements in its detection and treatment. Therefore, it is strategically important to be able to precisely charac-terize an individual's sensitivity to certain illnesses. The discovery of genes linked to cardio-vascular illnesses has benefited from linkage analysis and genome-wide association research. The last 20 years have seen significant advancements in the field of molecular genetics, particularly with the development of new tools like genome-wide association studies. In this article we explore the profound impact of genetic variations on disease development, prognosis, and therapeutic responses. And the significance of genetics in cardiovascular risk assessment and the ever -evolving realm of genetic testing, offering insights into the potential for personalized medicine in this domain. Embracing the future of cardiovascular care, the article explores the implications of pharmacogenomics for tailored treatments, the promise of emerging technologies in cardio-vascular genetics and therapies, including the transformative influence of nanotechnology. Furthermore, it delves into the exciting frontiers of gene editing, such as CRISPR/Cas9, as a novel approach to combat cardiovascular diseases. And also explore the potential of stem cell therapy and regenerative medicine, providing a holistic view of the dynamic landscape of cardiovascular genomics and its transformative potential for the field of cardiovascular medicine.
引用
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页数:10
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