Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager-horticulturalists

被引：19

作者：

Gatz, Margaret ^{[1
]}

Mack, Wendy J. ^{[2
]}

Chui, Helena C. ^{[3
]}

Law, E. Meng ^{[4
]}

Barisano, Giuseppe ^{[5
]}

Sutherland, M. Linda ^{[6
]}

Sutherland, James D. ^{[6
]}

Rodriguez, Daniel Eid ^{[7
]}

Gutierrez, Raul Quispe ^{[8
]}

Adrian, Juan Copajira ^{[8
]}

Cuata, Jesus Bani ^{[8
]}

Borenstein, Amy R. ^{[9
]}

Walters, Ellen E. ^{[1
]}

Irimia, Andrei ^{[10
,11
]}

Rowan, Christopher J. ^{[12
]}

Wann, L. Samuel ^{[13
]}

Allam, Adel H. ^{[14
]}

Thompson, Randall C. ^{[15
]}

Miyamoto, Michael, I ^{[16
]}

Michalik, David E. ^{[17
]}

Cummings, Daniel K. ^{[18
]}

Seabright, Edmond ^{[19
]}

Garcia, Angela R. ^{[20
]}

Hooper, Paul L. ^{[19
]}

Kraft, Thomas S. ^{[21
]}

Finch, Caleb E. ^{[10
]}

Thomas, Gregory S. ^{[22
,23
]}

Stieglitz, Jonathan ^{[24
]}

Trumble, Benjamin C. ^{[20
]}

Gurven, Michael D. ^{[21
]}

Kaplan, Hillard ^{[18
]}

机构：

[1] Univ Southern Calif, Ctr Econ & Social Res, 635 Downey Way, Los Angeles, CA 90089 USA

[2] Univ Southern Calif, Keck Sch Med, Dept Populat & Publ Hlth Sci, Los Angeles, CA 90089 USA

[3] Univ Southern Calif, Keck Sch Med, Dept Neurol, Los Angeles, CA 90089 USA

[4] Monash Univ, Dept Neurosci, Melbourne, Vic, Australia

[5] Univ Southern Calif, Neurosci Grad Program, Los Angeles, CA 90089 USA

[6] MemorialCare Hlth Syst, Fountain Valley, CA USA

[7] San Simon Univ, Fac Med, Inst Biomed Res, Cochabamba, Bolivia

[8] Tsimane Hlth & Life Hist Project, San Borja, Beni, Bolivia

[9] Univ Calif San Diego, Sch Med, Herbert Wertheim Sch Publ Hlth & Human Longev Sci, Div Epidemiol, La Jolla, CA 92093 USA

[10] Univ Southern Calif, Leonard Davis Sch Gerontol, Los Angeles, CA 90089 USA

[11] Univ Southern Calif, Corwin D Denney Res Ctr, Viterbi Sch Engn, Dept Biomed Engn, Los Angeles, CA 90089 USA

[12] Renown Inst Heart & Vasc Hlth, Reno, NV USA

[13] Univ New Mexico, Div Cardiol, Albuquerque, NM 87131 USA

[14] Al Azhar Univ, Sch Med, Dept Cardiol, Cairo, Egypt

[15] Univ Missouri, St Lukes Mid Amer Heart Inst, Kansas City, MO 64110 USA

[16] Providence Hlth, Mission Viejo, CA USA

[17] Mem Care Miller Womens & Childrens Hosp, Long Beach, CA USA

[18] Chapman Univ, Argyos Sch Business & Econ, Econ Sci Inst, Orange, CA USA

[19] Univ New Mexico, Dept Anthropol, Albuquerque, NM 87131 USA

[20] Arizona State Univ, Ctr Evolut & Med, Sch Human Evolut & Social Change, Tempe, AZ USA

[21] Univ Calif Santa Barbara, Dept Anthropol, Santa Barbara, CA 93106 USA

[22] MemorialCare Heart & Vasc Inst, Fountain Valley, CA USA

[23] Univ Calif Irvine, Div Cardiol, Orange, CA 92668 USA

[24] Inst Adv Study Toulouse, Toulouse, France

来源：

ALZHEIMERS & DEMENTIA | 2023年 / 19卷 / 01期

基金：

美国国家卫生研究院;

关键词：

cognitive dysfunction; dementia; mental status and dementia tests; Moseten; Tsimane; MINI-MENTAL STATE; ALZHEIMERS-DISEASE; ASSOCIATION; EDUCATION; TSIMANE; VERSION; HEALTH; RISK; KICA; AGE;

D O I：

10.1002/alz.12626

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction We evaluated the prevalence of dementia and mild cognitive impairment (MCI) in indigenous Tsimane and Moseten, who lead a subsistence lifestyle. Methods Participants from population-based samples >= 60 years of age (n = 623) were assessed using adapted versions of the Modified Mini-Mental State Examination, informant interview, longitudinal cognitive testing and brain computed tomography (CT) scans. Results Tsimane exhibited five cases of dementia (among n = 435; crude prevalence = 1.2%, 95% confidence interval [CI]: 0.4, 2.7); Moseten exhibited one case (among n = 169; crude prevalence = 0.6%, 95% CI: 0.0, 3.2), all age >= 80 years. Age-standardized MCI prevalence was 7.7% (95% CI: 5.2, 10.3) in Tsimane and 9.8% (95% CI: 4.9, 14.6) in Moseten. Cognitive impairment was associated with visuospatial impairments, parkinsonian symptoms, and vascular calcification in the basal ganglia. Discussion The prevalence of dementia in this cohort is among the lowest in the world. Widespread intracranial medial arterial calcifications suggest a previously unrecognized, non-Alzheimer's disease (AD) dementia phenotype.

引用

页码：44 / 55

页数：12

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