Comparative screening of anti-dengue activity in aqueous and ethanol extracts of mangrove plants from Sabah

被引:0
|
作者
Misrah, Mayrlidzatul Farhain [1 ]
Yusof, Nur Athirah [1 ]
Amin, Zarina [1 ]
Audah, Kholis Abdurachim [2 ]
Mokhtar, Ruzaidi Azli Mohd [1 ]
机构
[1] Univ Malaysia Sabah, Biotechnol Res Inst, Jalan UMS, Kota Kinabalu 88400, Sabah, Malaysia
[2] Swiss German Univ, Dept Biomed Engn, Tangerang 15143, Indonesia
关键词
Anti; -dengue; dengue virus; DENV2; NS2B-NS3pro; mangrove; rhizophora apiculata;
D O I
10.21161/mjm.230012
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Aims: Dengue virus is a global pathogen that lacks an effective vaccine or therapy. Screening medicinal plants for antidengue properties provides a promising avenue to identify potent compounds. Mangroves, known for their resilience in harsh conditions, produce a diverse range of natural products with unique biochemical profiles, which hold potential for anti-dengue treatments. This study aims to evaluate the anti-dengue activity of selected mangrove plant species from Sabah against DENV2 NS2B-NS3pro, utilizing an enzymatic protease assay.Methodology and results: Six mangrove species (Avicennia marina, Bruguiera gymnorrhiza, Ceriops tagal, Rhizophora apiculata, Rhizophora mucronata and Xylocarpus granatum) were investigated, with various plant parts subjected to aqueous and ethanol extraction. The results demonstrated significant anti-dengue activity in both aqueous and ethanolic extracts of the mangroves against DENV2 NS2B-NS3pro, with IC50 values ranging from 0.95 mu g/mL to 6.24 mu g/mL. Notably, the ethanolic extract of R. apiculata leaves exhibited the highest inhibition, with an IC50 value of 0.95 mu g/mL. Conclusion, significance and impact of study: These findings suggest that the ethanolic extracts from R. apiculata leaves hold promise as potential candidates for dengue treatment. This study underscores the importance of natural products as valuable sources for the development of novel anti-dengue treatments, highlighting the need to explore mangroves in the quest for effective therapeutic options.
引用
收藏
页码:671 / 677
页数:7
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