The provisional OMERACT ultrasonography score for giant cell arteritis

被引：50

作者：

Dejaco, Christian ^{[1
,2
]}

Ponte, Cristina ^{[3
,4
]}

Monti, Sara ^{[5
,6
]}

Rozza, Davide ^{[7
]}

Scire, Carlo Alberto ^{[8
]}

Terslev, Lene ^{[9
,10
]}

Bruyn, George A. W. ^{[11
]}

Boumans, Dennis ^{[12
]}

Hartung, Wolfgang ^{[13
]}

Hocevar, Alojzija ^{[14
,15
]}

Milchert, Marcin ^{[16
]}

Dohn, Uffe Moller ^{[17
]}

Mukhtyar, Chetan B. ^{[18
]}

Aschwanden, Markus ^{[19
]}

Bosch, Philipp ^{[1
]}

Camellino, Dario ^{[20
]}

Chrysidis, Stavros ^{[21
]}

Ciancio, Giovanni ^{[22
]}

D'Agostino, Maria Antonietta ^{[23
,24
]}

Daikeler, Thomas ^{[25
]}

Dasgupta, Bhaskar ^{[26
]}

De Miguel, Eugenio ^{[27
]}

Diamantopoulos, Andreas P. ^{[28
]}

Duftner, Christina ^{[29
]}

Agueda, Ana ^{[30
]}

Fredberg, Ulrich ^{[31
,32
]}

Hanova, Petra ^{[33
,34
]}

Hansen, Ib Tonder ^{[35
]}

Hauge, Ellen-Margrethe ^{[36
,37
]}

Iagnocco, Annamaria ^{[38
]}

Inanc, Nevsun ^{[39
]}

Juche, Aaron ^{[40
]}

Karalilova, Rositsa ^{[41
]}

Kawamoto, Toshio ^{[42
,43
]}

Keller, Kresten Krarup ^{[36
,37
]}

Keen, Helen Isobel ^{[44
]}

Kermani, Tanaz A. ^{[45
]}

Kohler, Minna J. ^{[46
]}

Koster, Matthew ^{[46
]}

Luqmani, Raashid Ahmed ^{[47
]}

Macchioni, Pierluigi ^{[48
]}

Mackie, Sarah Louise ^{[49
]}

Naredo, Esperanza ^{[50
,51
]}

Nielsen, Berit Dalsgaard ^{[36
,52
]}

Ogasawara, Michihiro ^{[43
]}

Pineda, Carlos ^{[53
]}

Schafer, Valentin Sebastian ^{[54
]}

Seitz, Luca ^{[55
]}

Tomelleri, Alessandro ^{[56
]}

Torralba, Karina D. ^{[57
]}

机构：

[1] Med Univ Graz, Dept Rheumatol, Graz, Steiermark, Austria

[2] Brunico Hosp, Dept Rheumatol, Trentino Alto Adige, Italy

[3] Ctr Hosp Univ Lisboa Norte, Ctr Acad Med Lisboa, Dept Rheumatol, Lisbon, Portugal

[4] Univ Lisbon, Ctr Acad Med Lisboa, Fac Med, Inst Med Mol,Rheumatol Res Unit, Lisbon, Portugal

[5] Univ Pavia, Dept Internal Med & Therapeut, Pavia, Italy

[6] Fdn IRCCS Policlin San Matteo, Div Rheumatol, Pavia, Italy

[7] Italian Soc Rheumatol, Milan, Italy

[8] Italian Soc Rheumatol SIR, Epidemiol Unit, Milan, Italy

[9] Rigshosp, Ctr Rheumatol & Spine Dis, Copenhagen, Denmark

[10] Univ Copenhagen, Clin Med, Copenhagen, Denmark

[11] Reumaklin Lelystad, Lelystad, Netherlands

[12] Hosp Grp Twente, Rheumatol & Clin Immunol, Almelo, Netherlands

[13] Asklepios Med Ctr, Rheumatol, Bad Abbach, Germany

[14] Univ Med Ctr Ljubljana, Dept Rheumatol, Ljubljana, Slovenia

[15] Univ Ljubljana, Med Fac, Ljubljana, Slovenia

[16] Pomeranian Med Univ, Dept Rheumatol Internal Med Geriatr & Clin Immuno, Szczecin, Poland

[17] Rigshosp, Copenhagen Ctr Arthrit Res COPECARE, Ctr Rheumatol & Spine Dis, Glostrup, Denmark

[18] Norfolk & Norwich Univ Hosp NHS Trust, Rheumatol Dept, Vasculitis Serv, Norwich, Norfolk, England

[19] Univ Hosp Basel, Angiol, Basel, Switzerland

[20] Azienda Sanitaria Locale 3 Genovese, Div Rheumatol, Dept Med Specialties, Genoa, Italy

[21] Sydvestjysk Sygehus Esbjerg, Rheumatol, Esbjerg, Denmark

[22] Univ Ferrara, Dept Med Sci, Ferrara, Italy

[23] Fdn Policlin Univ A Gemelli, Rheumatol Dept, Rome, Italy

[24] INSERM, Paris, France

[25] Univ Hosp Basel, Clin Rheumatol, Basel, Switzerland

[26] Southend Univ Hosp, Mid & South Essex Univ Hosp NHS Fdn Trust, Westcliff On Sea, England

[27] Hosp Univ La Paz, Madrid, Spain

[28] Akershus Univ Hosp, Div Internal Med, Sect Rheumatol, Lorenskog, Norway

[29] Med Univ Innsbruck, Dept Internal Med, Clin Div Internal Med 2, Innsbruck, Austria

[30] Ctr Hosp Baixo Vouga EPE, Aveiro, Portugal

[31] Silkeborg Reg Hosp, Diagnost Ctr, Silkeborg, Denmark

[32] Odense Univ Hosp, Rheumatol, Odense, Denmark

[33] Inst Rheumatol, Rheumatol, Prague, Czech Republic

[34] Hana CB Spol Sro, Rheumatol, Ceske Budejovice, Czech Republic

[35] Aarhus Copenhagen Hosp, Dept Rheumatol, Aarhus, Denmark

[36] Aarhus Univ Hosp, Dept Rheumatol, Aarhus, Denmark

[37] Aarhus Univ, Dept Clin Med, Aarhus, Denmark

[38] Univ Torino, Acad Rheumatol Ctr, Dipartimento Sci Clin & Biol, Turin, Italy

[39] Marmara Univ, Rheumatol, Sch Med, Istanbul, Turkey

[40] Immanuel Hosp, Dept Rheumatol, Berlin, Germany

[41] Med Univ Plovdiv, Clin Rheumatol, Plovdiv, Bulgaria

[42] Juntendo Univ, Immunol, Sch Med, Tokyo, Japan

[43] Juntendo Univ, Dept Internal Med & Rheumatol, Sch Med, Tokyo, Japan

[44] UWA, Med & Pharmacol, Perth, WA, Australia

[45] Univ Calif Los Angeles, David Geffen Sch Med, Rheumatol, Los Angeles, CA USA

[46] Harvard Med Sch, Div Rheumatol Allergy & Immunol, Massachusetts Gen Hosp, Boston, MA 02115 USA

[47] Univ Oxford, Nuffield Dept Orthopaedicx Rheumatol & Musculoske, Oxford, England

[48] Arcispedale Santa Maria Nuova, Reggio Emilia, Italy

[49] Univ Leeds, Leeds, W Yorkshire, England

[50] Hosp Univ Fdn Jimenez Diaz, Dept Rheumatol, IIS Fdn Jimenez Diaz, Madrid, Spain

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2023年 / 82卷 / 04期

关键词：

giant cell arteritis; ultrasonography; outcome assessment; health care; systemic vasculitis; ULTRASOUND; TOCILIZUMAB; SONOGRAPHY; TRIAL;

D O I：

10.1136/ard-2022-223367

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity in giant cell arteritis (GCA) and evaluate its metric properties. Methods: The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the OMERACT ultrasonography large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise was conducted using images of bilateral common temporal arteries, parietal and frontal branches as well as axillary arteries from 16 patients with GCA and 7 controls. Sensitivity to change and convergent construct validity were tested using data from a prospective cohort of patients with new GCA in which ultrasound-based intima-media thickness (IMT) measurements were conducted at weeks 1, 3, 6, 12 and 24. Results: Agreement was obtained (92.7%) for the OMERACT GCA Ultrasonography Score (OGUS), calculated as follows: sum of IMT measured in every segment divided by the rounded cut-off values of IMTs in each segment. The resulting value is then divided by the number of segments available. Thirty-five members conducted the reliability exercise, the interrater intraclass correlation coefficient (ICC) for the OGUS was 0.72-0.84 and the median intrareader ICC was 0.91. The prospective cohort consisted of 52 patients. Sensitivity to change between baseline and each follow-up visit up to week 24 yielded standardised mean differences from -1.19 to -2.16, corresponding to large and very large magnitudes of change, respectively. OGUS correlated moderately with erythrocyte sedimentation rate, C reactive protein and Birmingham Vasculitis Activity Score (corr(coeff) 0.37-0.48). Conclusion: We developed a provisional OGUS for potential use in clinical trials.

引用

页码：556 / 564

页数：9

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