Diagnostic and prognostic value of c-MYC gene expression in hematological malignancies

被引：1
|
作者：
Okafor, Ifeyinwa Maryann [1 ]
Okoroiwu, Henshaw Uchechi [1 ,2 ]
Ogar, Christopher Ogar [1 ]
机构：
[1] Univ Calabar, Fac Med Lab Sci, Dept Haematol & Blood Transfus Sci, Calabar, Nigeria
[2] Arthur Jarvis Univ, Fac Basic Med Sci, Dept Med Lab Sci, Akpabuyo, Nigeria
来源：
AFRICAN HEALTH SCIENCES | 2023年 / 23卷 / 02期
关键词：
c-MYC; c-MYC screening; prognosis with c-MYC; hematological malignancies; plasma c-MYC; c-MYC in malignan-cies; c-MYC expression; CELL-GROWTH; PREVALENCE; APOPTOSIS;
D O I：
10.4314/ahs.v23i2.30
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Introduction: c-MYC plays vital role in regulation of cell proliferation and has been associated with tumorigenesis. This study is aimed at assessing diagnostic and prognostic value of plasma c-MYC expression to aid in early diagnosis and prognosis of hematological malignancies.Methods: Plasma c-MYC expression was determined by quantitative real time PCR using EVA Green chemistry and cluster of differentiation markers performed via immunocytochemistry.Result: Plasma c-MYC was higher in subject with hematological malignancies (8.8 & PLUSMN; 1.1) when compared with apparently healthy controls (4.5 & PLUSMN; 0.5). A screening cut-off c-MYC ratio value of 9.42 with sensitivity and specificity of 65.5% and 100% respectively were obtained using receiver operator characteristic curve analysis. Plasma c-MYC was found to have no prognostic value using Kaplan-Meier analysis.Conclusion: Plasma c-MYC ratio showed promising screening/diagnostic value for hematological malignancies.
引用
收藏
页码：265 / 273
页数：9
相关论文
共 50 条
  • [1] EXPRESSION OF THE C-MYC GENE IN HUMAN GASTROINTESTINAL MALIGNANCIES
    TSUBOI, K
    HIRAYOSHI, K
    TAKEUCHI, K
    SABE, H
    SHIMADA, Y
    OHSHIO, G
    TOBE, T
    HATANAKA, M
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 146 (02) : 699 - 704
  • [2] c-myc expression in medulloblastoma and its prognostic value
    Herms, J
    Neidt, I
    Lüscher, B
    Sommer, A
    Schürmann, P
    Schröder, T
    Bergmann, M
    Wilken, B
    Probst-Cousin, S
    Hernáiz-Driever, P
    Behnke, J
    Hanefeld, F
    Pietsch, T
    Kretzschmar, HA
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2000, 89 (05) : 395 - 402
  • [3] Prognostic Value of c-MYC Expression in Patients with Peripheral Neuroblastic Tumors
    Zhang, Feng
    Tian, Zhuo
    Li, Tinghong
    Hu, Xianjun
    Zhu, Jin
    [J]. INTERNATIONAL JOURNAL OF GENERAL MEDICINE, 2021, 14 : 2901 - 2907
  • [4] Inhibition of c-Myc Expression and Function in Hematologic Malignancies
    Issa, Ghayas C.
    Delmore, Jake E.
    McKeown, Michael R.
    Lemieux, Madeleine E.
    Rahl, Peter B.
    Jacobs, Hannah M.
    Kastritis, Efstathios
    Gilpatrick, Timothy
    Paranal, Ronald M.
    Qi, Jun
    Shi, Junwei
    Chesi, Marta
    Schinzel, Anna C.
    Vakoc, Christopher R.
    Bergsagel, P. Leif
    Richardson, Paul G.
    Young, Richard
    Hahn, William C.
    Ghobrial, Irene M.
    Anderson, Kenneth C.
    Kung, Andrew L.
    Mitsiades, Constantine S.
    Bradner, James E.
    [J]. BLOOD, 2011, 118 (21) : 613 - 614
  • [5] C-myc and c-fos in human osteosarcoma:: Prognostic value of mRNA and protein expression
    Gamberi, G
    Benassi, MS
    Bohling, T
    Ragazzini, P
    Molendini, L
    Sollazzo, MR
    Pompetti, F
    Merli, M
    Magagnoli, G
    Balladelli, A
    Picci, P
    [J]. ONCOLOGY, 1998, 55 (06) : 556 - 563
  • [6] EXPRESSION OF C-MYC GENE IN HUMAN HEPATOMA
    SU, TS
    LIN, LH
    LUI, WY
    CHANG, CM
    CHOU, CK
    TING, LP
    HU, CP
    HAN, SH
    PENG, FK
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 132 (01) : 264 - 268
  • [7] CONTROL OF C-MYC GENE-EXPRESSION
    WILKIE, NM
    LANG, J
    WHITELAW, B
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 1986, : 102 - 102
  • [8] C-myc expression as a new prognostic factor in melanoma
    Stanislawek, A
    [J]. EUROPEAN JOURNAL OF CANCER, 1999, 35 : S371 - S371
  • [9] The prognostic value of c-myc oncoprotein levels in malignant melanoma
    Ekwobi, C. C.
    [J]. JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 2008, 61 (04): : 464 - 464
  • [10] Prognostic relevance of c-myc gene expression in giant-cell tumor of bone
    Gamberi, G
    Benassi, MS
    Böhling, T
    Ragazzini, P
    Molendini, L
    Sollazzo, MR
    Merli, M
    Ferrari, C
    Magagnoli, G
    Bertoni, F
    Picci, P
    [J]. JOURNAL OF ORTHOPAEDIC RESEARCH, 1998, 16 (01) : 1 - 7
12345