Growth differentiation factor 11: A new hope for the treatment of cardiovascular diseases

被引：3
|
作者：
Shao, Yingchun [1 ]
Wang, Yanhong [1 ]
Xu, Jiazhen [1 ]
Yuan, Yang [1 ]
Xing, Dongming [1 ,2 ,3 ]
机构：
[1] Qingdao Univ, Affiliated Hosp, Qingdao Canc Inst, Qingdao 266071, Peoples R China
[2] Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
[3] Qingdao Univ, Affiliated Hosp, Qingdao 266071, Peoples R China
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2023年 / 71-72卷
关键词：
Growth differentiation factor 11; GDF11; Myocardial injury; Cardiovascular diseases; Apoptosis; SKELETAL-MUSCLE; CELL DIFFERENTIATION; STEM-CELLS; GDF11; EXPRESSION; MYOSTATIN; INJURY; AGE; PROLIFERATION; NEUROGENESIS;
D O I：
10.1016/j.cytogfr.2023.06.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor-& beta; superfamily that has garnered significant attention due to its anti-cardiac aging properties. Many studies have revealed that GDF11 plays an indispensable role in the onset of cardiovascular diseases (CVDs). Consequently, it has emerged as a potential target and novel therapeutic agent for CVD treatment. However, currently, no literature reviews comprehensively summarize the research on GDF11 in the context of CVDs. Therefore, herein, we comprehen-sively described GDF11's structure, function, and signaling in various tissues. Furthermore, we focused on the latest findings concerning its involvement in CVD development and its potential for clinical translation as a CVD treatment. We aim to provide a theoretical basis for the prospects and future research directions of the GDF11 application regarding CVDs.
引用
收藏
页码：82 / 93
页数：12
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