Molecular chaperones in stroke-induced immunosuppression

被引：3
|
作者：
Qiao, Haoduo [1 ,2 ,3 ,4 ]
Xu, Qing [1 ,2 ,3 ,4 ]
Xu, Yunfei [1 ,2 ,3 ,4 ]
Zhao, Yao [1 ,2 ,3 ,4 ]
He, Nina [1 ,2 ,3 ,4 ]
Tang, Jie [5 ]
Zhao, Jie [1 ,2 ,3 ,4 ]
Liu, Ying [1 ,2 ,3 ,4 ]
机构：
[1] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha, Hunan, Peoples R China
[2] Cent South Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha, Hunan, Peoples R China
[3] Sepsis Translat Med Key Lab Hunan Prov, Changsha, Hunan, Peoples R China
[4] Natl Med Funct Expt Teaching Ctr, Changsha, Hunan, Peoples R China
[5] Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha, Hunan, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2023年 / 18卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Hsp70; Hsp72; Hsp90; HspB5; hypothalamic-pituitary-adrenal axis; molecular chaperones; neuroprotection; stroke; stroke-induced immunosuppression; sympathetic nervous system; HEAT-SHOCK PROTEINS; GLYCOGEN-SYNTHASE KINASE-3-BETA; TRANSIENT FOCAL ISCHEMIA; PROTEASOME INHIBITION; CEREBRAL-ISCHEMIA; UP-REGULATION; MOUSE MODEL; BRAIN; MECHANISMS; HSP70;
D O I：
10.4103/1673-5374.373678
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Stroke-induced immunosuppression is a process that leads to peripheral suppression of the immune system after a stroke and belongs to the central nervous system injury-induced immunosuppressive syndrome. Stroke-induced immunosuppression leads to increased susceptibility to post-stroke infections, such as urinary tract infections and stroke-associated pneumonia, worsening prognosis. Molecular chaperones are a large class of proteins that are able to maintain proteostasis by directing the folding of nascent polypeptide chains, refolding misfolded proteins, and targeting misfolded proteins for degradation. Various molecular chaperones have been shown to play roles in stroke-induced immunosuppression by modulating the activity of other molecular chaperones, cochaperones, and their associated pathways. This review summarizes the role of molecular chaperones in stroke-induced immunosuppression and discusses new approaches to restore host immune defense after stroke.
引用
收藏
页码：2638 / 2644
页数：7
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