Investigation of antibacterial activity of silver nanoparticles against staphylococcus aureus strain Silver nanoparticles

Aim: Staphylococcus aureus (S. aureus) is an important pathogen that causes hospital and community infections. Silver nanoparticles (AgNPs) have antimicrobial activity against both gram-positive and gram-negative bacteria. Colloidal silver (Ag) based antiseptics have become more popular once again because of the increase in antibiotic resistance. Silver nanoparticles mostly show their effectiveness against bacteria by disrupting bacterial DNA replication and bacterial cytoplasm membranes. In this study, it was aimed to investigate the antibacterial effect of silver nanoparticles against S. aureus strain. Material and Methods: The antibacterial effect of AgNPs was investigated against S. aureus ATCC 6538 reference strain. The Broth dilution method was used in the analysis of Minimum Inhibitory Concentration (MIC) values of silver nanoparticles. Brain Heart Infusion (BHI) agar plates were used in the Minimum Bactericidal Concentration (MBC) test. Results: The investigation showed that silver nanoparticles, at a concentration of 1 mg/ml, were effective against S. aureus. Discussion: As a result, the antibacterial activity of silver nanoparticles has been determined and further research is required.