Pleosmaranes A-R, Isopimarane and 20-nor Isopimarane Diterpenoids with Anti-inflammatory Activities from the Mangrove Endophytic Fungus Pleosporales sp. HNQQJ-1

被引：4

作者：

Wang, Guisheng ^{[1
,2
,3
]}

Yuan, Yilin ^{[2
]}

Li, Zhaokun ^{[1
]}

Liu, Xuguang ^{[2
]}

Chu, Yanhai ^{[2
]}

She, Zhigang ^{[3
]}

Kang, Wenyi ^{[2
]}

Chen, Yan ^{[1
,2
]}

机构：

[1] Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China

[2] Henan Univ, Natl R&D Ctr Edible Fungus Proc Technol, Kaifeng 475004, Peoples R China

[3] Sun Yat Sen Univ, Sch Chem, Guangzhou 510275, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2024年 / 87卷 / 02期

基金：

中国国家自然科学基金;

关键词：

DERIVATIVES;

D O I：

10.1021/acs.jnatprod.3c00893

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Pleosmaranes A-R (1-18), 18 new isopimarane-type diterpenoids, together with four known analogs (19-22), were isolated from the mangrove endophytic fungus Pleosporales sp. HNQQJ-1. Their structures and absolute configurations were established by analysis of their spectroscopic data and electronic circular dichroism (ECD) calculations. Compounds 1-9 possess an unusual aromatic B ring and a 20-nor-isopimarane skeleton. Compounds 15-17 contain a unique 2-oxabicyclo[2.2.2]octane moiety. Compound 18 features an unexpected 2-oxabicyclo[3.2.1]octane moiety. Compounds 8 and 12 exhibited a moderate inhibitory effect against LPS-induced NO production, with IC50 values of 19 and 25 mu M, respectively.

引用

页码：304 / 314

页数：11

共 16 条

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