Studying a propionic acidaemia mouse model reveals epigenetic mechanisms in the heart

被引：0
|
作者：
Swietach, Pawel [1 ]
Park, Kyung Chan [1 ]
机构：
[1] Univ Oxford, Dept Physiol, Oxford, England
来源：
NATURE CARDIOVASCULAR RESEARCH | 2023年 / 2卷 / 12期
关键词：
D O I：
10.1038/s44161-023-00371-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We show how a build-up of propionyl-CoA in a mouse model of propionic acidaemia produces histone modifications in the heart. The transcriptional responses included genes implicated in contractile dysfunction. Notably, female mice are more severely affected, owing to a protective effect of beta-alanine in males, a therapeutically important finding.
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页码：1125 / 1126
页数：2
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