Endothelial Dysfunction in Diabetes Mellitus: New Insights

被引：10

作者：

Dubsky, Michal ^{[1
,2
]}

Veleba, Jiri ^{[1
]}

Sojakova, Dominika ^{[1
,2
]}

Marhefkova, Natalia ^{[1
,2
]}

Fejfarova, Vladimira ^{[1
]}

Jude, Edward B. ^{[3
,4
]}

机构：

[1] Inst Clin & Expt Med, Diabet Ctr, Prague 14021, Czech Republic

[2] Charles Univ Prague, Fac Med 1, Prague 14021, Czech Republic

[3] Tameside & Glossop Integrated Care NHS Fdn Trust, Diabet Ctr, Ashton Under Lyne OL6 9RW, England

[4] Univ Manchester, Dept Endocrinol & Gastroenterol, Manchester M13 9PL, England

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 13期

关键词：

endothelial dysfunction; diabetes mellitus; vascular health; arterial stiffness; YOUNG-ADULTS; FATTY-ACIDS; TYPE-1; ATHEROSCLEROSIS; OMEGA-3-FATTY-ACIDS; MECHANISMS; BIOMARKERS; MORTALITY; THICKNESS; INSULIN;

D O I：

10.3390/ijms241310705

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endothelial dysfunction (ED) is an important marker of future atherosclerosis and cardiovascular disease, especially in people with diabetes. This article summarizes the evidence on endothelial dysfunction in people with diabetes and adds different perspectives that can affect the presence and severity of ED and its consequences. We highlight that data on ED in type 1 diabetes are lacking and discuss the relationship between ED and arterial stiffness. Several interesting studies have been published showing that ED modulates microRNA, microvesicles, lipid levels, and the endoplasmatic reticulum. A better understanding of ED could provide important insights into the microvascular complications of diabetes, their treatment, and even their prevention.

引用

页数：12

共 50 条

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