Altersolanol B, a fungal metabolite, induces proteasome-dependent degradation of estrogen receptor a (ERα) and inhibits downstream signaling targets in ER plus breast adenocarcinoma cells

被引:0
|
作者
Siraj, Md Afjalus
Rahman, Md Sajjadur
Jacobs, Aaron T.
Tan, Ghee T.
机构
关键词
D O I
10.1158/1538-7445.SABCS22-P2-24-08
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
P2-24-08
引用
收藏
页数:2
相关论文
共 23 条
  • [1] Docosahexaenoic acid induces proteasome-dependent degradation of estrogen receptor α and inhibits the downstream signaling target in MCF-7 breast cancer cells
    Lu, I-Fen
    Hasio, Ann-Che
    Hu, Meng-Chun
    Yang, Feng-Ming
    Su, Hui-Min
    JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2010, 21 (06): : 512 - 517
  • [2] Hypoxia induces proteasome-dependent degradation of estrogen receptor a in ZR-75 breast cancer cells
    Stoner, M
    Saville, B
    Wormke, M
    Dean, D
    Burghardt, R
    Safe, S
    MOLECULAR ENDOCRINOLOGY, 2002, 16 (10) : 2231 - 2242
  • [3] Altersolanol B, a fungal tetrahydroanthraquinone, inhibits the proliferation of estrogen receptor-expressing (ER plus ) human breast adenocarcinoma by modulating PI3K/AKT, p38/ERK MAPK and associated signaling pathways
    Siraj, Md Afjalus
    Jacobs, Aaron T.
    Tan, Ghee T.
    CHEMICO-BIOLOGICAL INTERACTIONS, 2022, 359
  • [4] Proteasome inhibition represses ERα gene expression in ER plus cells: a new link between proteasome activity and estrogen signaling in breast cancer
    Powers, G. L.
    Ellison-Zelski, S. J.
    Casa, A. J.
    Lee, A. V.
    Alarid, E. T.
    ONCOGENE, 2010, 29 (10) : 1509 - 1518
  • [5] Estrogen Therapy Induces Receptor-Dependent DNA Damage Enhanced by PARP Inhibition in ER plus Breast Cancer
    Traphagen, Nicole A.
    Schwartz, Gary N.
    Tau, Steven
    Roberts, Alyssa M.
    Jiang, Amanda
    Hosford, Sarah R.
    Marotti, Jonathan D.
    Goen, Abigail E.
    Romo, Bianca A.
    Johnson, Anneka L.
    Duffy, Emily-Claire K.
    Demidenko, Eugene
    Heverly, Paul
    Mosesson, Yaron
    Soucy, Shannon M.
    Kolling, Fred
    Miller, Todd W.
    CLINICAL CANCER RESEARCH, 2023, 29 (18) : 3717 - 3728
  • [6] Estrogen therapy induces receptor-dependent DNA damage enhanced by PARP inhibition in ER plus breast cancer
    Traphagen, Nicole
    Schwartz, Gary
    Tau, Steven
    Roberts, Alyssa
    Jiang, Amanda
    Hosford, Sarah
    Marotti, Jonathan
    Goen, Abigail
    Romo, Bianca
    Johnson, Anneka
    Duffy, Emily
    Demidenko, Eugene
    Heverly, Paul
    Mosesson, Yaron
    Soucy, Shannon
    Kolling, Fred
    Miller, Todd
    CANCER RESEARCH, 2024, 84 (09)
  • [7] A fusion protein of the estrogen receptor (ER) and nuclear receptor corepressor (NCoR) strongly inhibits estrogen-dependent responses in breast cancer cells
    Chien, PY
    Ito, M
    Park, Y
    Tagami, T
    Gehm, BD
    Jameson, JL
    MOLECULAR ENDOCRINOLOGY, 1999, 13 (12) : 2122 - 2136
  • [8] Novel aspects of degradation of T cell receptor subunits from the endoplasmic reticulum (ER) in T cells: Importance of oligosaccharide processing, ubiquitination, and proteasome-dependent removal from ER membranes
    Yang, M
    Omura, S
    Bonifacino, JS
    Weissman, AM
    JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (06): : 835 - 846
  • [9] Silibinin Induces Apoptosis and Inhibits Proliferation of Estrogen Receptor (ER)-Negative Breast Carcinoma Cells through Suppression of Nuclear Factor Kappa B Activation
    Yousefi, Meysam
    Ghaffari, Seyed H.
    Zekri, Ali
    Hassani, Saeed
    Alimoghaddam, Kamran
    Ghavamzadeh, Ardeshir
    ARCHIVES OF IRANIAN MEDICINE, 2014, 17 (05) : 366 - 371