Nutrition dose in the early acute phase of critical illness: Finding the sweet spot and heeding the lessons from the NUTRIREA trials

被引：7

作者：

Patel, Jayshil J. ^{[1
,6
]}

Rice, Todd W. ^{[2
]}

Mundi, Manpreet S. ^{[3
]}

Stoppe, Christian ^{[4
]}

McClave, Stephen A. ^{[5
]}

机构：

[1] Med Coll Wisconsin, Dept Med, Div Pulm & Crit Care Med, Milwaukee, WI USA

[2] Vanderbilt Univ, Dept Med, Div Allergy Pulm & Crit Care Med, Nashville, TN USA

[3] Mayo Clin, Dept Med, Div Endocrinol Diabet Metab & Nutr, Rochester, MN USA

[4] Univ Hosp, Dept Anesthesiol Intens Care Emergency & Pain Med, Wuerzberg, Germany

[5] Univ Louisville, Dept Med, Div Gastroenterol Hepatol & Nutr, Louisville, KY USA

[6] Med Coll Wisconsin, Div Pulm & Crit Care Med, 9200 West Wisconsin Ave,HUB,8th Floor, Milwaukee, WI 53226 USA

来源：

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION | 2023年 / 47卷 / 07期

关键词：

circulatory shock; critical illness; enteral nutrition; nutrition support; nutrition therapy; parenteral nutrition; PARALLEL-GROUP; ORGAN FAILURE; ILL; MULTICENTER; SEPSIS; MICROBIOME; MANAGEMENT; PATHOBIOME; AUTOPHAGY; ADULTS;

D O I：

10.1002/jpen.2539

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The landmark NUTRIREA-2 and NUTRIREA-3 trials compared the route and dose of nutrition, respectively, in critically ill patients with circulatory shock. The results of both trials support a "less-is-more" paradigm shift in the early acute phase of critical illness. In this review, the authors outline and appraise the results of the NUTRIREA-2 and NUTRIREA-3 trials, introduce the concept of identifying the "sweet spot" for nutrition dose based on severity of illness/nutrition risk and nutrition dose, and identify the unintended consequences of delivering full-dose nutrition in sicker critically ill patients during the early acute phase of critical illness.

引用

页码：859 / 865

页数：7