Molecular mechanisms controlling vertebrate retinal patterning, neurogenesis, and cell fate specification

被引:4
|
作者
Zhang, Xin [1 ,2 ]
Leavey, Patrick [3 ]
Appel, Haley [3 ]
Makrides, Neoklis [1 ]
Blackshaw, Seth [3 ,4 ,5 ,6 ,7 ,8 ]
机构
[1] Columbia Univ, Sch Med, Dept Ophthalmol, New York, NY 10027 USA
[2] Columbia Univ, Sch Med, Dept Pathol & Cell Biol, New York, NY 10027 USA
[3] Johns Hopkins Univ, Sch Med, Solomon H Snyder Dept Neurosci, Baltimore, MD 21218 USA
[4] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD USA
[5] Johns Hopkins Univ, Sch Med, Dept Ophthalmol, Baltimore, MD 21218 USA
[6] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21218 USA
[7] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21218 USA
[8] Johns Hopkins Univ, Sch Med, Kavli Neurosci Discovery Inst, Baltimore, MD 21218 USA
基金
美国国家卫生研究院;
关键词
NUCLEAR RECEPTOR NR2E3; GANGLION-CELL; TRANSCRIPTION-FACTOR; GENE-EXPRESSION; SONIC-HEDGEHOG; PHOTORECEPTOR DIFFERENTIATION; PIGMENT EPITHELIUM; CONE PHOTORECEPTORS; ROD PHOTORECEPTORS; EYE DEVELOPMENT;
D O I
10.1016/j.tig.2023.06.002
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
This review covers recent advances in understanding the molecular mechanisms controlling neurogenesis and specification of the developing retina, with a focus on insights obtained from comparative single cell multiomic analysis. We discuss recent advances in understanding the mechanisms by which extrinsic factors trigger transcriptional changes that spatially pattern the optic cup (OC) and control the initiation and progression of retinal neurogenesis. We also discuss progress in unraveling the core evolutionarily conserved gene regulatory networks (GRNs) that specify early- and late-state retinal progenitor cells (RPCs) and neurogenic progenitors and that control the final steps in determining cell identity. Finally, we discuss findings that provide insight into regulation of speciesspecific aspects of retinal patterning and neurogenesis, including consideration of key outstanding questions in the field.
引用
收藏
页码:736 / 757
页数:22
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