Analgesic and Anti-inflammatory Effects of Montelukast in Chicks

THE GOAL of the study was to assess the analgesic and anti-inflammatory properties of montelukast in chicks. Methods: The oral median analgesic effective dose (ED50) of montelukast was determined by the up-and-down method. An electrical stimulator was used to determine the analgesia of montelukast over time. Formalin test was used to determine the analgesic and anti-inflammatory activities of montelukast. Results: oral median analgesic effective dose (ED50) of montelukast was 9.23 mg/kg. Montelukast (18 and 36 mg/kg) had significant analgesic activity over time compared with a control group, and the peak of analgesia of montelukast was observed later one hour of treatment. Montelukast showed significant analgesic and antiinflammatory activities in the formalin test, represented by a significant increase in the commencement of lifting the right foot, a decrease in the number of lifting the right foot, and significant a decrease in the thickness of the paw in comparison to control group. Conclusion: Montelukast possesses noteworthy effects of eliminating pain and inflammation in chicks.