Insights on E1-like enzyme ATG7: functional regulation and relationships with aging-related diseases

被引：6
|
作者：
Liu, Jingwei [1 ,2 ,3 ]
Xiao, Yutong [1 ,2 ]
Cao, Liangzi [1 ,2 ]
Lu, Songming [1 ,2 ]
Zhang, Siyi [1 ,2 ]
Yang, Ruohan [1 ,2 ]
Wang, Yubang [1 ,2 ]
Zhang, Naijin [1 ,4 ]
Yu, Yang [1 ,2 ]
Wang, Xiwen [5 ]
Guo, Wendong [1 ,2 ]
Wang, Zhuo [1 ,2 ]
Xu, Hongde [1 ,2 ]
Xing, Chengzhong [3 ]
Song, Xiaoyu [1 ,2 ]
Cao, Liu [1 ,2 ]
机构：
[1] China Med Univ, Hlth Sci Inst, Coll Basic Med Sci, Shenyang, Liaoning, Peoples R China
[2] China Med Univ, Key Lab Precis Diag & Treatment Gastrointestinal T, Minist Publ Hlth, Key Lab Cell Biol,Minist Educ,Liaoning Prov Collab, Shenyang 110122, Liaoning, Peoples R China
[3] China Med Univ, Dept Anus & Intestine Surg, Affiliated Hosp 1, Shenyang, Liaoning, Peoples R China
[4] China Med Univ, Hosp 1, Dept Cardiol, Key Lab Environm Stress & Chron Dis Control & Prev, Shenyang, Liaoning, Peoples R China
[5] China Med Univ, Dept Thorac Surg, Shengjing Hosp, Shenyang, Liaoning, Peoples R China
来源：
COMMUNICATIONS BIOLOGY | 2024年 / 7卷 / 01期
关键词：
HEPATOCELLULAR-CARCINOMA CELLS; INHIBITS AUTOPHAGY; PROMOTES AUTOPHAGY; LUNG-CANCER; ATG7-MEDIATED AUTOPHAGY; OXIDATIVE STRESS; CYTOSOLIC FOXO1; DOWN-REGULATION; E2; RECRUITMENT; IN-VITRO;
D O I：
10.1038/s42003-024-06080-1
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Autophagy is a dynamic self-renovation biological process that maintains cell homeostasis and is responsible for the quality control of proteins, organelles, and energy metabolism. The E1-like ubiquitin-activating enzyme autophagy-related gene 7 (ATG7) is a critical factor that initiates classic autophagy reactions by promoting the formation and extension of autophagosome membranes. Recent studies have identified the key functions of ATG7 in regulating the cell cycle, apoptosis, and metabolism associated with the occurrence and development of multiple diseases. This review summarizes how ATG7 is precisely programmed by genetic, transcriptional, and epigenetic modifications in cells and the relationship between ATG7 and aging-related diseases. A review summarizes how ATG7 is precisely programmed by genetic, transcriptional, and epigenetic modifications in cells and its functions, including the relationship between ATG7 and aging-related diseases.
引用
收藏
页数：15
相关论文
共 15 条
  • [1] Insights on E1-like enzyme ATG7: functional regulation and relationships with aging-related diseases
    Jingwei Liu
    Yutong Xiao
    Liangzi Cao
    Songming Lu
    Siyi Zhang
    Ruohan Yang
    Yubang Wang
    Naijin Zhang
    Yang Yu
    Xiwen Wang
    Wendong Guo
    Zhuo Wang
    Hongde Xu
    Chengzhong Xing
    Xiaoyu Song
    Liu Cao
    Communications Biology, 7
  • [2] The FAP motif within human ATG7, an autophagy-related E1-like enzyme, is essential for the E2-substrate reaction of LC3 lipidation
    Tanida, Isei
    Yamasaki, Manabu
    Komatsu, Masaaki
    Ueno, Takashi
    AUTOPHAGY, 2012, 8 (01) : 88 - 97
  • [3] Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8
    Seung Beom Hong
    Byeong-Won Kim
    Kyung-Eun Lee
    Se Woong Kim
    Hyesung Jeon
    Joon Kim
    Hyun Kyu Song
    Nature Structural & Molecular Biology, 2011, 18 : 1323 - 1330
  • [4] Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8
    Hong, Seung Beom
    Kim, Byeong-Won
    Lee, Kyung-Eun
    Kim, Se Woong
    Jeon, Hyesung
    Kim, Joon
    Song, Hyun Kyu
    NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2011, 18 (12) : 1323 - U32
  • [5] E1-Like Activating Enzyme Atg7 Is Preferentially Sequestered into p62 Aggregates via Its Interaction with LC3-I
    Gao, Wentao
    Chen, Zhixia
    Wang, Wei
    Stang, Michael T.
    PLOS ONE, 2013, 8 (09):
  • [6] Discovery and optimization of inhibitors of the autophagy E1 enzyme, ATG7
    Huang, Shih-Chung
    Harrison, Sean
    Gould, Alexandra
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257
  • [7] A cancer associated somatic mutation in LC3B attenuates its binding to E1-like ATG7 protein and subsequent lipidation
    Nuta, Gal Chaim
    Gilad, Yuval
    Gershoni, Moran
    Sznajderman, Arielle
    Schlesinger, Tomer
    Bialik, Shani
    Eisenstein, Miriam
    Pietrokovski, Shmuel
    Kimchi, Adi
    AUTOPHAGY, 2019, 15 (03) : 438 - 452
  • [8] NEW INSIGHTS INTO THE ROLE OF THE GH-IGF SYSTEM IN THE REGULATION OF LIFESPAN AND AGING-RELATED DISEASES IN HUMANS
    Cohen, P.
    GERONTOLOGIST, 2012, 52 : 261 - 261
  • [9] Role of AMBRA1 in mitophagy regulation: emerging evidence in aging-related diseases
    Di Rienzo, Martina
    Romagnoli, Alessandra
    Refolo, Giulia
    Vescovo, Tiziana
    Ciccosanti, Fabiola
    Zuchegna, Candida
    Lozzi, Francesca
    Occhigrossi, Luca
    Piacentini, Mauro
    Fimia, Gian Maria
    AUTOPHAGY, 2024, 20 (12) : 2602 - 2615
  • [10] Role of MST1 in the regulation of autophagy and mitophagy: implications for aging-related diseases
    Shang, Huayu
    VanDusseldorp, Trisha A.
    Ma, Ranggui
    Zhao, Yan
    Cholewa, Jason
    Zanchi, Nelo Eidy
    Xia, Zhi
    JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 2022, 78 (04) : 709 - 719
12