Solid-State Silver-Catalyzed Ring-Opening Fluorination of Cyclobutanols by Using Mechanochemistry

In this report, we demonstrate that a ball-milling technique facilitates fast and efficient silver-catalyzed ring-opening fluorination of cyclobutanols. This is the first report of a catalytic C-C bond-cleav-age/functionalization reaction under solid-state mechanochemical con-ditions. The developed protocol affords a high yield of ?-fluorinated ke-tones within much shorter reaction times, and requires less silver catalyst and Selectfluor compared with the previous solution-based conditions. Notably, the process can be carried out in air. Because of the reduced use of chemicals and the simple time-saving experimental pro-cedures, this technique is an efficient and environmentally friendly way to access ?-fluorinated ketones.