Diabetic kidney disease is one of the most serious complications of diabetes. Although diabetic kidney disease can be effectively controlled through strict blood glucose management and corresponding symptomatic treatment, these therapies cannot reduce its incidence in diabetic patients. The sodium-glucose co -transporter 2 (SGLT2) inhibitors and the traditional Chinese herb "Gegen" have been widely used in diabetes-related therapy. However, it remains unclear whether the combined use of these two kinds of medicines contributes to an increased curative effect on diabetic kidney disease. In this study, we examined this issue by evaluat-ing the efficacy of the combination of puerarin, an active ingredient of Gegen, and canagliflozin, an SGLT2 inhibitor for a 12-week intervention using a mouse model of diabetes. The results indicated that the combination of puerarin and canagliflozin was superior to canagliflozin alone in improving the metabolic and renal function parameters of diabetic mice. Our findings suggested that the renoprotective effect of combined puerarin and canagliflozin in diabetic mice was achieved by reducing re-nal lipid accumulation. This study provides a new strategy for the clinical prevention and treatment of diabetic kidney disease. The puerarin and SGLT2 inhibitor combina-tion therapy at the initial stage of diabetes may effectively delay the occurrence of diabetic kidney injury, and significantly alleviate the burden of renal lipotoxicity.
机构:
Changchun Univ Tradit Chinese Med, Changchun 130117, Jilin, Peoples R ChinaChangchun Univ Tradit Chinese Med, Changchun 130117, Jilin, Peoples R China
Li Ang
Liu Yuguang
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Changchun Univ Tradit Chinese Med, Changchun 130117, Jilin, Peoples R ChinaChangchun Univ Tradit Chinese Med, Changchun 130117, Jilin, Peoples R China
Liu Yuguang
Wang Liying
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Changchun Univ Tradit Chinese Med, Changchun 130117, Jilin, Peoples R ChinaChangchun Univ Tradit Chinese Med, Changchun 130117, Jilin, Peoples R China
Wang Liying
Zhang Shuying
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Changchun Univ Tradit Chinese Med, Changchun 130117, Jilin, Peoples R ChinaChangchun Univ Tradit Chinese Med, Changchun 130117, Jilin, Peoples R China
Zhang Shuying
Xu Liting
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Changchun Univ Tradit Chinese Med, Changchun 130117, Jilin, Peoples R ChinaChangchun Univ Tradit Chinese Med, Changchun 130117, Jilin, Peoples R China
Xu Liting
Wang Shumin
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Changchun Univ Tradit Chinese Med, Changchun 130117, Jilin, Peoples R ChinaChangchun Univ Tradit Chinese Med, Changchun 130117, Jilin, Peoples R China
机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R China
Fourth Mil Med Univ, Tangdu Hosp, Dept Cardiol, Xian, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R China
Xiong, Zhenyu
Li, Yueyang
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Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R China
Li, Yueyang
Zhao, Zhengqing
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h-index: 0
机构:
Second Mil Med Univ, Changzheng Hosp, Dept Neurol, Shanghai, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R China
Zhao, Zhengqing
Zhang, Yan
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机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R China
Zhang, Yan
Man, Wanrong
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Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R China
Man, Wanrong
Lin, Jie
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Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R China
Lin, Jie
Dong, Yuan
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h-index: 0
机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R China
Dong, Yuan
Liu, Liyuan
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h-index: 0
机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R China
Liu, Liyuan
Wang, Bo
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Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R China
Wang, Bo
Wang, Huan
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Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R China
Wang, Huan
Guo, Baolin
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机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R China
Guo, Baolin
Li, Congye
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h-index: 0
机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R China
Li, Congye
Li, Fei
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h-index: 0
机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R China
Li, Fei
Wang, Haichang
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h-index: 0
机构:
Xian Int Med Ctr, Heart Hosp, 16 Tuanjie South Rd, Xian 710038, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R China
Wang, Haichang
Sun, Dongdong
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机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R China
Sun, Dongdong
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,
2020,
1866
(08):
机构:
Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
YIN Lin
CHEN Xi
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
CHEN Xi
LI Na
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
LI Na
JIA Wei-hua
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
JIA Wei-hua
WANG Nuo-qi
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
WANG Nuo-qi
HOU Bi-yu
论文数: 0引用数: 0
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机构:
Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
HOU Bi-yu
QIANG Gui-fen
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
QIANG Gui-fen
YANG Xiu-ying
论文数: 0引用数: 0
h-index: 0
机构:
Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
YANG Xiu-ying
DU Guan-hua
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h-index: 0
机构:
Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
机构:
Jiangnan Univ, Wuxi Sch Med, Wuxi, Peoples R ChinaJiangnan Univ, Wuxi Sch Med, Wuxi, Peoples R China
Wang, Hui
Wang, Wei
论文数: 0引用数: 0
h-index: 0
机构:
Xuzhou Med Univ, Clin Med Sch 2, Xuzhou, Jiangsu, Peoples R ChinaJiangnan Univ, Wuxi Sch Med, Wuxi, Peoples R China
Wang, Wei
Jiang, Yao
论文数: 0引用数: 0
h-index: 0
机构:
Jiangnan Univ, Wuxi Sch Med, Wuxi, Peoples R ChinaJiangnan Univ, Wuxi Sch Med, Wuxi, Peoples R China
Jiang, Yao
Cui, Siyuan
论文数: 0引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Affiliated Wuxi Peoples Hosp 2, Wuxi, Peoples R ChinaJiangnan Univ, Wuxi Sch Med, Wuxi, Peoples R China
Cui, Siyuan
Kong, Yulin
论文数: 0引用数: 0
h-index: 0
机构:
Jiangnan Univ, Wuxi Sch Med, Wuxi, Peoples R ChinaJiangnan Univ, Wuxi Sch Med, Wuxi, Peoples R China
Kong, Yulin
Chen, Yong Q.
论文数: 0引用数: 0
h-index: 0
机构:
Jiangnan Univ, Wuxi Sch Med, Wuxi, Peoples R China
Jiangnan Univ, MOE Med Basic Res Innovat Ctr Gut Microbiota & Chr, Sch Med, Wuxi, Peoples R ChinaJiangnan Univ, Wuxi Sch Med, Wuxi, Peoples R China
Chen, Yong Q.
Zhu, Shenglong
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h-index: 0
机构:
Jiangnan Univ, Wuxi Sch Med, Wuxi, Peoples R ChinaJiangnan Univ, Wuxi Sch Med, Wuxi, Peoples R China
机构:
Shenzhen Univ Gen Hosp, Dept Endocrinol & Metab, Shenzhen, Peoples R ChinaShenzhen Univ Gen Hosp, Dept Endocrinol & Metab, Shenzhen, Peoples R China
Wang, Y.
Wang, L.
论文数: 0引用数: 0
h-index: 0
机构:
City Univ Hong Kong, Dept Biomed Sci, Hong Kong, Peoples R ChinaShenzhen Univ Gen Hosp, Dept Endocrinol & Metab, Shenzhen, Peoples R China
Wang, L.
Huang, Y.
论文数: 0引用数: 0
h-index: 0
机构:
City Univ Hong Kong, Dept Biomed Sci, Hong Kong, Peoples R ChinaShenzhen Univ Gen Hosp, Dept Endocrinol & Metab, Shenzhen, Peoples R China