Progress in diagnosis and treatment of difficult-to-treat asthma in children

被引：0

作者：

Zhou, Xuehua ^{[1
]}

Zhang, Panpan ^{[1
]}

Tan, Hong ^{[1
]}

Dong, Bo ^{[1
]}

Jing, Zenghui ^{[1
]}

Wu, Huajie ^{[1
]}

Luo, Jianfeng ^{[1
]}

Zhang, Yao ^{[1
]}

Zhang, Juan ^{[1
]}

Sun, Xin ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp, Dept Pediat, 127 Changle West Rd, Xian 710032, Shaanxi, Peoples R China

来源：

THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE | 2023年 / 17卷

基金：

中国国家自然科学基金;

关键词：

children; diagnosis and evaluation; difficult-to-treat asthma; treatment; EXHALED NITRIC-OXIDE; MYCOPLASMA-PNEUMONIAE INFECTION; PROBLEMATIC SEVERE ASTHMA; POORLY CONTROLLED ASTHMA; VOCAL CORD DYSFUNCTION; GASTROESOPHAGEAL-REFLUX; SYSTEMATIC ASSESSMENT; EOSINOPHILIC ASTHMA; AIRWAY INFLAMMATION; ALLERGIC RHINITIS;

D O I：

10.1177/17534666231213637

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

At present, medications containing inhaled corticosteroids (ICS-containing) are the keystones of asthma treatment. The majority of asthmatic children can significantly improve clinical outcomes with little worsening by standardized inhaled glucocorticoid treatment, but there is still a small proportion of children who are unable to achieve good symptom control even after the maximum standardized treatment, known as 'children with difficult-to-treat asthma (DA)'. The high heterogeneity of DA makes therapy challenging and expensive, which poses a serious risk to children's health and makes it extremely difficult for clinical physicians to accurately identify and treat children with DA. This article reviews the definition, evaluation, and treatment of this asthma in order to provide a reference for optimal clinical decision-making.

引用

页数：24

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