Repeatability and Reproducibility of Corneoscleral Topography Measured With Scheimpflug Imaging in Keratoconus and Control Eyes

Objectives:To determine and compare the repeatability and reproducibility of anterior scleral parameters measured by the corneoscleral profile (CSP) module of Pentacam in keratoconus (KC) and control eyes.Methods:This is a prospective observational study. Thirty KC participants (30 eyes) and 24 control participants (24 eyes) were examined three times using the CSP. Sagittal height mean (SHM), sagittal height astigmatism (SHA), and mean bulbar slope (BSM) were measured in 12 mm and 16 mm chord lengths. The repeatability and reproducibility of these measurements were also assessed. Coefficients of variation (CoV), intraclass correlation coefficient (ICC), coefficient of repeatability (CoR1), and coefficient of reproducibility (CoR2) were adopted to assess the reliability.Results:In the KC and control groups, SHM showed high repeatability and reproducibility (coefficients of variation [CoVs]<= 0.96%, intraclass correlation coefficient [ICCs]>= 0.97), and SHM of control eyes showed higher repeatability and reproducibility than that of KC eyes at 12 mm chord length (KC group, CoRs ranged from 35.56 mu m to 43.52 mu m, control group, ranged from 23.50 mu m to 30.31 mu m) and 16 mm chord length (KC group, CoRs ranged from 79.54 mu m to 81.58 mu m, control group, ranged from 48.25 mu m to 66.10 mu m). Mean bulbar slope also showed high repeatability and reproducibility (CoVs <= 3.65%, CoRs <= 2.64). Furthermore, the SHA of control eyes showed higher repeatability and reproducibility when compared with KC eyes (control group: CoVs <= 29.95%, KC group: CoVs >= 32.67%).Conclusions:Keratoconus and control eyes demonstrated high repeatability and reproducibility when using CSP measurements, which may prove helpful in fitting contact lenses.