Long-term persistence of IgG antibodies in recovered COVID-19 individuals at 18 months post-infection and the impact of two-dose BNT162b2 (Pfizer-BioNTech) mRNA vaccination on the antibody response: Analysis using fixed-effects linear regression model

被引：2

作者：

Dehgani-Mobaraki, Puya ^{[1
,6
]}

Wang, Chao ^{[2
]}

Floridi, Alessandro ^{[3
]}

Floridi, Emanuela ^{[3
]}

Dawoodi, Sunny ^{[4
]}

Zaidi, Asiya K. ^{[5
]}

机构：

[1] Umbria Reg Registry Volunteer Act, Assoc Naso Sano, Via Luca Benincasa 2, I-06073 Perugia, Italy

[2] Univ London, Kingston Univ & St Georges, Fac Hlth Social Care & Educ, Hlth & Social Care Stat, London SW17 0RE, England

[3] Ctr Ric Anal Biochim Specialist, Perugia, Italy

[4] RIPAS Hosp, Bandar Seri Begawan, Brunei

[5] Assoc Naso Sano, Umbria Reg Registry Volunteer Act & Res, San Mariano, Italy

[6] Assoc Naso Sano, Educ & Res, Perugia, Italy

来源：

VIROLOGY | 2023年 / 578卷

关键词：

D O I：

10.1016/j.virol.2022.12.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This era of emerging variants needs a thorough evaluation of data on the long-term efficacy of immune responses in vaccinated as well as recovered individuals, to understand the overall evolution of the pandemic. In this study, we aimed to assess the dynamics of IgG response over 18 months in n = 36 patients from the Umbria region in Italy, who had a documented history of COVID-19 infection in March 2020, and then compared the impact of two-dose BNT162b2 (Pfizer-BioNTech) vaccination on the antibody responses of these patients with the ones who did not receive any dose of vaccine. This is the longest observation (March 2020-September 2021) for the presence of antibodies against SARS-CoV-2 in recovered individuals along with the impact of 2 dose-BNT162b2 vaccination on these responses. Fixed-effect regression models were used for statistical analysis which could be also used to predict future titer trends. At 18 months, 97% participants tested positive for anti-NCP hinting towards the persistence of infection-induced immunity even for the vaccinated individuals. Our study findings demonstrate that while double dose vaccination boosted the IgG levels in recovered individuals 161 times, this "boost " was relatively short-lived. The unvaccinated recovered in-dividuals, in contrast, continued to show a steady decline but detectable antibody levels. Further studies are required to re-evaluate the timing and dose regimen of vaccines for an adequate immune response in recovered individuals.

引用

页码：111 / 116

页数：6