Optical coherence tomography is state-of-the-art in non-invasive imaging of biological structures. Spectral Domain Optical Coherence Tomography is the popularly used variation of this technique, but its performance is limited by the bandwidth and resolution of the system. In this work, we theoretically formulate the use of phase modulators and delay lines to act as filters on the tomography system and scan multiple channels. Various channels are then combined in a digital computer using filter bank theory to improve the sampling rate. The combination of multiple channels allows for increasing the axial resolution and maximum unambiguous range beyond the Nyquist limit. We then simulate the multirate spectral domain optical coherence tomography with 2 channels. We show that a single delay line can improve the axial resolution while a pair of phase modulators can improve the maximum unambiguous range of the system. We also show the use of multirate filter banks to carry out this process. Thus, by using a few extra components in the spectral domain optical coherence tomography, its performance can be increased manifold depending on the number of channels used. The extra cost is the time taken to perform the extra scans that is trivial for stationary objects like biological tissues.
机构:
Zhejiang Univ, State Key Lab Modern Opt Instrumentat, Hangzhou 310027, Peoples R ChinaZhejiang Univ, State Key Lab Modern Opt Instrumentat, Hangzhou 310027, Peoples R China
Wang, Kai
Ding, Zhihua
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Zhejiang Univ, State Key Lab Modern Opt Instrumentat, Hangzhou 310027, Peoples R ChinaZhejiang Univ, State Key Lab Modern Opt Instrumentat, Hangzhou 310027, Peoples R China
机构:
Calif Pacific Med Ctr, Dept Ophthalmol, San Francisco, CA USA
Stanford Univ, Sch Med, Dept Ophthalmol, Stanford, CA USA
UCSF Sch Med, Francis I Proctor Fdn, San Francisco, CA USACalif Pacific Med Ctr, Dept Ophthalmol, San Francisco, CA USA
Cunningham, Emmett T., Jr.
van Velthoven, Mirjam E. J.
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Rotterdam Eye Hosp, Uveitis & Med Retina Serv, Rotterdam, NetherlandsCalif Pacific Med Ctr, Dept Ophthalmol, San Francisco, CA USA
van Velthoven, Mirjam E. J.
Zierhut, Manfred
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Univ Tubingen, Ctr Ophthalmol, Tubingen, GermanyCalif Pacific Med Ctr, Dept Ophthalmol, San Francisco, CA USA
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Univ Calif San Diego, Hamilton Glaucoma Ctr, 9500 Gilman Dr, La Jolla, CA 92093 USA
Univ Calif San Diego, Dept Ophthalmol, La Jolla, CA 92093 USAUniv Calif San Diego, Hamilton Glaucoma Ctr, 9500 Gilman Dr, La Jolla, CA 92093 USA
Medeiros, Felipe A.
Weinreb, Robert N.
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Univ Calif San Diego, Hamilton Glaucoma Ctr, 9500 Gilman Dr, La Jolla, CA 92093 USA
Univ Calif San Diego, Dept Ophthalmol, La Jolla, CA 92093 USAUniv Calif San Diego, Hamilton Glaucoma Ctr, 9500 Gilman Dr, La Jolla, CA 92093 USA
机构:
Sankara Nethralaya, Neuroophthalmol Serv, 18 Coll Rd, Chennai, Tamil Nadu, India
3-B Kanakakrishna Apartments, 83-14 2nd Main Rd, Chennai 20, Tamil Nadu, IndiaSankara Nethralaya, Neuroophthalmol Serv, 18 Coll Rd, Chennai, Tamil Nadu, India
Bassi, Shikha Talwar
Pamu, Ramesh
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Sankara Nethralaya, Neuroophthalmol Serv, Comprehens Ophthalmol, 18 Coll Rd, Chennai, Tamil Nadu, IndiaSankara Nethralaya, Neuroophthalmol Serv, 18 Coll Rd, Chennai, Tamil Nadu, India
Pamu, Ramesh
Varghese, Anjaly
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Sankara Nethralaya, Dept Optometry, 18 Coll Rd, Chennai, Tamil Nadu, IndiaSankara Nethralaya, Neuroophthalmol Serv, 18 Coll Rd, Chennai, Tamil Nadu, India