Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice

被引：0
|
作者：
Barbosa-de-Oliveira, Maria Clara [1 ]
Oliveira-Melo, Paolo [2 ]
da Silva, Marcos Henrique Goncalves [3 ]
da Silva, Flavio Santos [1 ]
da Silva, Felipe Andrade Carvalho [1 ]
de Araujo, Bruno Vinicios Silva [1 ]
de Oliveira, Moacir Franco [4 ]
Correia, Aristides Tadeu [2 ]
Sakamoto, Sidnei Miyoshi [1 ]
Valenca, Samuel Santos [5 ]
Lanzetti, Manuella [5 ]
Schmidt, Martina [6 ,7 ]
Kennedy-Feitosa, Emanuel [1 ]
机构：
[1] Fed Univ Semiarid Reg, Dept Hlth Sci, Morphophysiopharmacol Lab, BR-59625900 Mossoro, Brazil
[2] Univ Sao Paulo, Fac Med HCFMUSP, Lab Pesquisa Cirurgia Torac, BR-05508220 Sao Paulo, Brazil
[3] Fed Fluminense Univ UFF, Dept Clin Med, BR-24000000 Niteroi, Brazil
[4] Fed Univ Semiarid Reg, Dept Anim Sci, BR-59625900 Mossoro, Brazil
[5] Fed Univ Rio de Janeiro UFRJ, Inst Biomed Sci, BR-21941590 Rio De Janeiro, Brazil
[6] Univ Groningen, Dept Mol Pharmacol, Antonius Deusinglaan 1,Bldg 3211,Room 406, NL-9713 AV Groningen, Netherlands
[7] Univ Groningen, Univ Med Ctr Groningen, Groningen Res Inst Asthma & COPD, NL-9713 AV Groningen, Netherlands
来源：
ANTIOXIDANTS | 2023年 / 12卷 / 06期
关键词：
cigarette; macrophages; pulmonary inflammation; oxidative stress; eugenol; NF-KAPPA-B; OXIDATIVE STRESS; ANTIOXIDANT ACTIVITY; REDOX REGULATION; BARRIER FUNCTION; INFLAMMATION; AIRWAY; PATHOGENESIS; RESPONSES; ASTHMA;
D O I：
10.3390/antiox12061258
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This study investigates the role of eugenol (EUG) on CS-induced acute lung injury (ALI) and how this compound is able to modulate macrophage activity. C57BL/6 mice were exposed to 12 cigarettes/day/5days and treated 15 min/day/5days with EUG. Rat alveolar macrophages (RAMs) were exposed to CSE (5%) and treated with EUG. In vivo, EUG reduced morphological changes inflammatory cells, oxidative stress markers, while, in vitro, it induced balance in the oxidative stress and reduced the pro-inflammatory cytokine release while increasing the anti-inflammatory one. These results suggest that eugenol reduced CS-induced ALI and acted as a modulator of macrophage activity.
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页数：14
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