Diets Differently Regulate Pulmonary Pathogenesis and Immune Signaling in Mice during Acute and Chronic Mycobacterium tuberculosis Infection

被引:2
|
作者
Oswal, Neelam [1 ]
Thangavel, Hariprasad [1 ]
Lizardo, Kezia [1 ]
Dhanyalayam, Dhanya [1 ]
Sidrat, Tabinda [1 ]
Salgame, Padmini [2 ]
Nagajyothi, Jyothi F. [1 ]
机构
[1] Hackensack Meridian Hlth, Ctr Discovery & Innovat, Nutley, NJ 07110 USA
[2] Rutgers New Jersey Med Sch, Ctr Emerging Pathogens, Dept Med, Newark, NJ 07103 USA
来源
LIFE-BASEL | 2023年 / 13卷 / 01期
基金
美国国家卫生研究院;
关键词
Mycobacterium tuberculosis; C57BL; 6; mice; diet; adiponectin; adipogenesis; lipolysis; necrosis; immune cell; macrophage; inflammation;
D O I
10.3390/life13010228
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) infection persists as a leading cause of mortality and morbidity globally, especially in developing and underdeveloped countries. The prevalence of TB-DM (diabetes mellitus) is higher in low- and middle-income countries where TB and DM are most prevalent. Epidemiological data suggest that slight obesity reduces the risk of TB, whereas DM increases the risk of pulmonary TB. Diets can alter the levels of body fat mass and body mass index by regulating systemic adiposity. Earlier, using a transgenic Mtb-infected murine model, we demonstrated that loss of body fat increased the risk of pulmonary bacterial load and pathology. In the present study, we investigated whether increased adiposity alters pulmonary pathology and bacterial load using C57BL/6 mice infected with HN878 Mtb strain and fed a medium-fat diet (MFD). We analyzed the effects of MFD on the lung during acute and chronic infections by comparing the results to those obtained with infected mice fed a regular diet (RD). Histological and biochemical analyses demonstrated that MFD reduces bacterial burden by increasing the activation of immune cells in the lungs during acute infection and reduces necrosis in the lungs during chronic infection by decreasing lipid accumulation. Our data suggest that slight adiposity likely protects the host during active TB infection by regulating immune and metabolic conditions in the lungs.
引用
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页数:21
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