Integrating network pharmacology: The next-generation approach in ocular drug discovery

被引：3

作者：

Lazzara, Francesca ^{[1
]}

Conti, Federica ^{[1
]}

Giuffrida, Erika ^{[1
]}

Eandi, Chiara Maria ^{[2
,3
]}

Drago, Filippo ^{[1
,4
]}

Platania, Chiara Bianca Maria ^{[1
,4
]}

Bucolo, Claudio ^{[1
]}

机构：

[1] Univ Catania, Sch Med, Dept Biomed & Biotechnol Sci, Catania, Italy

[2] Univ Lausanne, Jules Gonin Eye Hosp, Fdn Asile Aveugles, Dept Ophthalmol, Lausanne, Switzerland

[3] Univ Torino, Dept Surg Sci, Turin, Italy

[4] Univ Catania, Ctr Res Ocular Pharmacol CERFO, Catania, Italy

来源：

CURRENT OPINION IN PHARMACOLOGY | 2024年 / 74卷

关键词：

Network pharmacology; Systems biology; Diabetic retinopathy; Age-related macular degeneration; Glaucoma; GINKGO-BILOBA;

D O I：

10.1016/j.coph.2023.102425

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

With the spread of the "omics" sciences, the approaches of systems biology can be considered as new paradigms of pharmacological research for discovery of novel targets and/or treatments for complex multifactorial diseases. Data from omics sciences can be used for the design of biologic networks, that in turn can be quantitatively analyzed to identify new pharmacological targets. In this review, we will introduce the concept of network pharmacology, particularly the application of this innovative approach in the field of ocular pharmacology, with a focus on retinal diseases such as diabetic and glaucoma.

引用

页数：6

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