Microneedles for delivery of anticancer therapeutics: recent trends and technologies

被引：2
|
作者：
Rana, Prinsy [1 ,2 ]
Dey, Asmita Deka [1 ]
Agarwal, Tarun [3 ]
Kumar, Arun [1 ,4 ]
机构：
[1] Chitkara Univ, Chitkara Coll Pharm, Rajpura, Punjab, India
[2] Maharishi Markendeshwar Univ, MM Coll Pharm, Mullana, Haryana, India
[3] Koneru Lakshmaiah Educ Fdn, Dept Biotechnol, Vaddeswaram, AP, India
[4] Cent Univ South Bihar, Sch Hlth Sci, Dept Pharm, Gaya 824209, India
来源：
JOURNAL OF NANOPARTICLE RESEARCH | 2023年 / 25卷 / 07期
关键词：
Anticancer therapy; Microneedles; Drug delivery; Gene delivery; Biosafety; Clinical translation; Nanostructures; TRANSDERMAL DRUG-DELIVERY; DISSOLVING MICRONEEDLES; 2-PHOTON POLYMERIZATION; CANCER-IMMUNOTHERAPY; PHOTOTHERMAL THERAPY; PROTEIN DELIVERY; GENE DELIVERY; SKIN; VACCINATION; FABRICATION;
D O I：
10.1007/s11051-023-05803-5
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Cancer tops the list of most life-threatening diseases worldwide, recording around 10 million deaths annually. Implementation of microneedles (MNs) as a therapeutic delivery vehicle has revolutionized anticancer therapy, thanks to MNs' minimally invasive and painless delivery aspect, high therapeutic efficacy, low cost, and relative biosafety. In this review, we overview the application of MNs for the delivery of different anticancer therapeutic and diagnostic modalities, including drugs, peptides, antibodies, gene, and vaccines. We further highlighted the fabrication strategies, materials, and therapeutic release patterns from MNs. Finally, we discussed biosafety concerns, translational aspects, limitations, and future perspective of MNs as an efficient anticancer theranostic system.
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页数：32
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