Bivariate GWAS reveals pleiotropic regions among feed efficiency and beef quality-related traits in Nelore cattle

被引：6

作者：

Buss, Carlos Eduardo ^{[1
,2
]}

Afonso, Juliana ^{[3
]}

de Oliveira, Priscila S. N. ^{[1
]}

Petrini, Juliana ^{[4
]}

Tizioto, Polyana Cristine ^{[5
]}

Cesar, Aline S. M. ^{[6
]}

Gustani-Buss, Emanuele Cristina ^{[2
,11
]}

Cardoso, Taina Figueiredo ^{[3
]}

Rovadoski, Gregori A. ^{[4
]}

da Silva Diniz, Wellison Jarles ^{[7
]}

de Lima, Andressa Oliveira ^{[8
]}

Rocha, Marina Ibelli Pereira ^{[1
]}

Andrade, Bruno Gabriel Nascimento ^{[3
,9
]}

Wolf, Jason B. ^{[10
]}

Coutinho, Luiz Lehmann ^{[4
]}

Mourao, Gerson Barreto ^{[4
]}

de Almeida Regitano, Luciana Correia ^{[3
]}

机构：

[1] Univ Fed Sao Carlos, Dept Genet & Evolut, Sao Carlos, SP, Brazil

[2] Mindflow Genom, Leuven, Flanders, Belgium

[3] Embrapa Southeast Cattle, Rodovia Washington Luiz,Km 234 S-N, Sao Carlos, SP, Brazil

[4] Univ Sao Paulo, ESALQ, Dept Anim Sci, Piracicaba, SP, Brazil

[5] NGS Solucoes Genom, Piracicaba, SP, Brazil

[6] Univ Sao Paulo, ESALQ, Dept Agroind Food & Nutr, Piracicaba, SP, Brazil

[7] Auburn Univ, Dept Anim Sci, Auburn, AL USA

[8] Univ Washington, Dept Genom Sci, Div Med Genet, Seattle, WA USA

[9] Munster Technol Univ, MTU, Dept Comp Sci, Cork, Ireland

[10] Univ Bath, Milner Ctr Evolut Bath, Dept Biol & Biochem, Bath BA2 7AY, England

[11] Katholieke Univ Leuven, Rega Inst, Dept Microbiol Immunol & Transplantat, B-3000 Leuven, Belgium

来源：

MAMMALIAN GENOME | 2023年 / 34卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

WHOLE-GENOME ASSOCIATION; MEAT QUALITY; CARCASS; PROTEIN; STEERS; REQUIREMENTS; PERFORMANCE; SYSTEM; FUTURE; GROWTH;

D O I：

10.1007/s00335-022-09969-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Feed-efficient cattle selection is among the most leading solutions to reduce cost for beef cattle production. However, technical difficulties in measuring feed efficiency traits had limited the application in livestock. Here, we performed a Bivariate Genome-Wide Association Study (Bi-GWAS) and presented candidate biological mechanisms underlying the association between feed efficiency and meat quality traits in a half-sibling design with 353 Nelore steers derived from 34 unrelated sires. A total of 13 Quantitative Trait Loci (QTL) were found explaining part of the phenotypic variations. An important transcription factor of adipogenesis in cattle, the TAL1 (rs133408775) gene located on BTA3 was associated with intramuscular fat and average daily gain (IMF-ADG), and a region located on BTA20, close to CD180 and MAST4 genes, both related to fat accumulation. We observed a low positive genetic correlation between IMF-ADG (r = 0.30 +/- 0.0686), indicating that it may respond to selection in the same direction. Our findings contributed to clarifying the pleiotropic modulation of the complex traits, indicating new QTLs for bovine genetic improvement.

引用

页码：90 / 103

页数：14

共 9 条

[1] Bivariate GWAS reveals pleiotropic regions among feed efficiency and beef quality-related traits in Nelore cattle
Carlos Eduardo Buss
Juliana Afonso
Priscila S. N. de Oliveira
Juliana Petrini
Polyana Cristine Tizioto
Aline S. M. Cesar
Emanuele Cristina Gustani-Buss
Tainã Figueiredo Cardoso
Gregori A. Rovadoski
Wellison Jarles da Silva Diniz
Andressa Oliveira de Lima
Marina Ibelli Pereira Rocha
Bruno Gabriel Nascimento Andrade
Jason B. Wolf
Luiz Lehmann Coutinho
Gerson Barreto Mourão
Luciana Correia de Almeida Regitano
[J]. Mammalian Genome, 2023, 34 : 90 - 103
[2] Selection criteria for feed efficiency-related traits and their association with growth, reproductive and carcass traits in Nelore cattle
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[3] Estimates of genetic and phenotypic parameters for feeding behaviour and feed efficiency-related traits in Nelore cattle
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[5] Genetic parameters and correlations of related feed efficiency, growth, and carcass traits in Hanwoo beef cattle
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[6] Potential Biomarkers for Feed Efficiency-Related Traits in Nelore Cattle Identified by Co-expression Network and Integrative Genomics Analyses
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de Oliveira, Priscila S. N.
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[J]. FRONTIERS IN GENETICS, 2020, 11
[7] New insights into the associations among feed efficiency, metabolizable efficiency traits and related QTL regions in broiler chickens
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[J]. Journal of Animal Science and Biotechnology, 2020, 11 (04) : 950 - 964
[8] New insights into the associations among feed efficiency, metabolizable efficiency traits and related QTL regions in broiler chickens
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[J]. JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY, 2020, 11 (01)
[9] New insights into the associations among feed efficiency, metabolizable efficiency traits and related QTL regions in broiler chickens
Wei Li
Ranran Liu
Maiqing Zheng
Furong Feng
Dawei Liu
Yuming Guo
Guiping Zhao
Jie Wen
[J]. Journal of Animal Science and Biotechnology, 11

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