Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance

被引：1

作者：

Fidelle, Marine ^{[1
,2
,3
]}

Tian, Ai-Ling ^{[2
,4
]}

Zitvogel, Laurence ^{[1
,3
,5
,6
,9
]}

Kroemer, Guido ^{[2
,4
,7
,8
]}

机构：

[1] Gustave Roussy, Metabol & Cell Biol Platforms, Villejuif, France

[2] Univ Paris Saclay, Gustave Roussy Canc Ctr, Metabol & Cell Biol Platforms, Villejuif, France

[3] Inserm U1015, Equipe Labellisee Ligue Canc, Villejuif, France

[4] Univ Paris, Sorbonne Univ, Inst Univ France, Ctr Rech Cordeliers,Equipe Labellisee Ligue Contr, Paris, France

[5] Univ Paris Saclay, Fac Med, Paris, France

[6] Ctr Clin Invest Biotherapies Canc CICBT BIOTHERIS, Dept Biol, Villejuif, France

[7] Hop Europeen Georges Pompidou, AP HP, Inst Canc Paris Carpem, Dept Biol, Paris, France

[8] Ctr Rech Cordeliers, Paris, France

[9] Gustave Roussy Canc Ctr, Villejuif, Paris, France

来源：

ONCOIMMUNOLOGY | 2023年 / 12卷 / 01期

基金：

欧盟地平线“2020”;

关键词：

Cancer immunotherapy; microbiota; immunosuppression; MAdCAM-1; bile acids; Enterocloster; gut;

D O I：

10.1080/2162402X.2023.2224672

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In a recent paper in Science, Fidelle et al. unravel a gut immune checkpoint that is subverted by antibiotic treatment. Post-antibiotic dysbiosis of the ileum causes an increase in bile acids that downregulate MAdCAM-1, thereby triggering the exodus of immunosuppressive T cells from gut-associated lymphoid tissues toward tumors.

引用

页数：4

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