Tumor Stimulus-Activatable Pretheranostic Agent: One Key to Three Locks

被引：3

作者：

Zhang, Yize ^{[1
,2
]}

Ni, Yingyong ^{[1
,2
]}

Zhao, Xuan ^{[1
,2
]}

Wang, Ting ^{[1
,2
]}

Zhu, Xiaojiao ^{[1
,2
]}

Sun, Xianshun ^{[1
,2
]}

Wang, Sen ^{[1
,2
]}

Li, Dandan ^{[1
,2
]}

Wang, Junjun ^{[2
,3
]}

Zhou, Hongping ^{[1
,2
]}

机构：

[1] Anhui Univ, Sch Chem & Chem Engn, Inst Phys Sci & Informat Technol, Ctr Free Electron Laser & High Magnet Field,Sch Ma, Hefei 230601, Peoples R China

[2] Anhui Univ, Key Lab Chem Inorgan Organ Hybrid Functionalized M, Hefei 230601, Peoples R China

[3] Anhui Univ, Sch Mat Sci & Engn, Ctr Atom Engn Adv Mat, Anhui Prov Key Lab Chem Inorgan Organ Hybrid Funct, Hefei 230601, Peoples R China

来源：

ANALYTICAL CHEMISTRY | 2023年 / 95卷 / 42期

基金：

中国国家自然科学基金;

关键词：

FLUORESCENT-PROBE; PHOTOSENSITIZER; CELLS; HCLO;

D O I：

10.1021/acs.analchem.3c02777

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The uncontrollable distribution of antitumor agents remains a large obstacle for specific and efficient cancer theranostics; thus, efficient construction of tumor-specific systems is highly desirable. In this work, a general design of tumor stimulus-activatable pretheranostic agents was put forward via a series of structures-tunable triphenylamine derivatives (TPA-2T-FSQ, TPA-2T-BSZ, and TPA-2T-ML) with phenothiazine, benzothiazine, and thiomorpholine as identifying groups of hypochlorite (HClO), respectively. Notably, the sulfur atom in phenothiazine of TPA-2T-FSQ was more easily oxidized to sulfoxide groups by HClO, transforming into an electron acceptor to form an excellent push-pull electronic system, which was beneficial to a large redshift of absorbance and emission wavelengths. Based on this, TPA-2T-FSQ resorted to a key of overexpressed HClO in the tumor to open "three locks", viz, NIR fluorescence, photothermal, and photoacoustic signals for multimodal diagnostic and treatment of the tumor. This study provided an elegant design to adopt tumor stimulus-triggerable pretheranostic for improving theranostic accuracy and efficiency, which was regarded as a promising candidate for precision medicine.

引用

页码：15636 / 15644

页数：9