Risk of Severe Alphaherpesvirus Infection after Solid Organ Transplantation: A Nationwide Population-Based Cohort Study

被引:1
|
作者
Chuang, Ya-Wen [1 ,2 ,3 ,4 ]
Huang, Shih-Ting [2 ,3 ,4 ]
Wang, I-Kuan [1 ,4 ,5 ]
Lo, Ying-Chih [6 ,7 ]
Chang, Chiz-Tzung [4 ,5 ]
Lin, Cheng-Li [4 ,8 ]
Yu, Tung-Min [1 ,3 ,4 ]
Li, Chi-Yuan [1 ,9 ]
机构
[1] China Med Univ, Grad Inst Biomed Sci, Taichung 404333, Taiwan
[2] Natl Chung Hsing Univ, Coll Med, Dept Postbaccalaureate Med, Taichung 40227, Taiwan
[3] Taichung Vet Gen Hosp, Dept Internal Med, Div Nephrol, Taichung 40705, Taiwan
[4] China Med Univ, Sch Med, Taichung 404333, Taiwan
[5] China Med Univ Hosp, Div Nephrol, Taichung 404333, Taiwan
[6] Brigham & Womens Hosp, Dept Med, Div Gen Internal Med & Primary Care, Boston, MA 02115 USA
[7] Harvard Med Sch, Boston, MA 02115 USA
[8] China Med Univ Hosp, Management Off Hlth Data, Taichung 404333, Taiwan
[9] China Med Univ Hosp, Dept Anesthesiol, Taichung 404333, Taiwan
关键词
solid organ transplant; alphaherpesvirus; herpes simplex virus; herpes zoster; cohort study; VARICELLA-ZOSTER-VIRUS; HERPES-ZOSTER; EPIDEMIOLOGY;
D O I
10.3390/biomedicines11020637
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Patients after solid organ transplantation (SOT) are more susceptible to various viral infections, including alphaherpesviruses. Therefore, the aim of our study was to investigate the risk of alphaherpesvirus infections, including herpes simplex and herpes zoster, after solid organ transplantation. Inpatient records from the Taiwan National Health Insurance Research Database (NHIRD) defined solid organ recipients, including heart, liver, lung, and kidney, hospitalized for alphaherpesvirus infections as a severe case group of transplants and matched them with a nontransplant cohort. We enrolled 18,064 individuals, of whom 9032 were in each group. A higher risk of severe alphaherpesvirus infection was noted in solid organ recipients (aHR = 9.19; p < 0.001) than in the general population. In addition, solid organ transplant recipients had the highest risk of alphaherpesvirus infection within 1 year after transplantation (aHR = 25.18). The comparison found a higher risk of herpes zoster and herpes simplex infections in recipients of kidney (aHR = 9.13; aHR = 12.13), heart (aHR = 14.34; aHR = 18.54), and liver (aHR = 5.90; aHR = 8.28) transplants. Patients who underwent solid organ transplantation had a significantly higher risk of alphaherpesvirus infection than the general population.
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页数:9
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