Pediatric immune-mediated necrotizing myopathy

被引：5
|
作者：
Wang, Chen-Hua [1 ,2 ]
Liang, Wen-Chen [2 ,3 ,4 ]
机构：
[1] Kaohsiung Municipal Hsiaokang Hosp, Dept Pediat, Kaohsiung, Taiwan
[2] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Pediat, Kaohsiung, Taiwan
[3] Kaohsiung Med Univ, Sch Med, Dept Pediat, Kaohsiung, Taiwan
[4] Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung, Taiwan
来源：
FRONTIERS IN NEUROLOGY | 2023年 / 14卷
关键词：
immune-mediated necrotizing myopathy; HMGCR; SRP; idiopathic inflammatory myopathy; juvenile myositis; SIGNAL RECOGNITION PARTICLE; JUVENILE MYOSITIS; REDUCTASE; AUTOANTIBODIES; ANTIBODIES; ANTI-3-HYDROXY-3-METHYLGLUTARYL-COENZYME; DISEASE; CLASSIFICATION; POLYMYOSITIS; RITUXIMAB;
D O I：
10.3389/fneur.2023.1123380
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Immune-mediated necrotizing myopathy (IMNM) is a type of inflammatory myopathy. Most patients with IMNM produce anti-3-hydroxy-3-methylglutaryl coenzyme A reductase or anti-signal-recognition particle autoantibodies. IMNM is much rarer in children than in adults. We conducted this mini review focusing on pediatric IMNM to present current evidence regarding its epidemiology, clinical characteristics, diagnosis, and treatment. Our findings indicate that pediatric IMNM often causes severe muscle weakness and is refractory to corticosteroids alone. Furthermore, delayed diagnosis is common because of the clinicopathological similarity between IMNM and inherited myopathy. Raising awareness regarding pediatric IMNM may facilitate early diagnosis and effective treatment.
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页数：10
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