Evaluation of eGFRs to Calculate Kidney Function in Adults with Severe Motor and Intellectual Disabilities

被引:2
|
作者
Uemura, Osamu [1 ]
Hasegawa, Yuka [2 ]
Nakashima, Hideaki [2 ]
Otobe, Yoshihiro [3 ]
机构
[1] Ichinomiya Med Treatment & Habilitat Ctr, Dept Pediat, Ichinomiya, Japan
[2] Ichinomiya Med Treatment & Habilitat Ctr, Dept Pharm, Ichinomiya, Japan
[3] Ichinomiya Med Treatment & Habilitat Ctr, Dept Rehabil, Ichinomiya, Japan
来源
JMA JOURNAL | 2023年 / 6卷 / 04期
关键词
validation; estimated glomerular filtration rate; severe motor and intellectual disabilities; creatinine; cystatin C; GLOMERULAR-FILTRATION-RATE; JAPANESE CHILDREN; CYSTATIN C; EQUATION; CREATININE;
D O I
10.31662/jmaj.2023-0069
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: The gold standard for evaluating kidney function is kidney inulin clearance (Cin). However, this procedure is difficult to perform in patients with neuromuscular disabilities and/or bladder dysfunction. We aimed to develop a sim-pler method for determining the estimated glomerular filtration rate (eGFR) using equations and values for three biomark-ers: serum creatinine (sCr), serum cystatin C (cysC), and serum beta-2 microglobulin ((32MG). This study evaluated three eGFR equations in patients with severe motor and intellectual disabilities (SMID). Methods: We evaluated the equations using data of 18 adult SMID patients with a clinical need for creatinine clearance (Ccr). We compared the results of each equation with Ccr-based eGFR instead of Cin using mean error (ME), root mean square error (RMSE), and P30. Results: Based on eGFR, the ME values of Cr, cysC, (32MG, and Ccr were 74.5, 2.3, and 6.5 mL/min/1.73 m2, RMSE values, 92.3, 25.7, and 33.4 mL/min/1.73 m2; and P30, 16.7%, 77.8%, and 72.2%, respectively. Conclusions: eGFR-Cr cannot be used to reliably assess kidney function in adult SMID patients. It is better to use eGFR-cysC to evaluate kidney function in this patient population.
引用
收藏
页码:481 / 486
页数:6
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