Evolution of the SARS-CoV-2 Omicron spike

被引：12
|
作者：
Parsons, Ruth J. [1 ,2 ]
Acharya, Priyamvada [1 ,2 ,3 ]
机构：
[1] Duke Human Vaccine Inst, Durham, NC 27710 USA
[2] Duke Univ, Dept Biochem, Durham, NC 27710 USA
[3] Duke Univ, Dept Surg, Durham, NC 27710 USA
来源：
CELL REPORTS | 2023年 / 42卷 / 12期
关键词：
RECEPTOR-BINDING DOMAIN; VARIANT;
D O I：
10.1016/j.celrep.2023.113444
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern, first identified in November 2021, rapidly spread worldwide and diversified into several subvariants. The Omicron spike (S) protein accumulated an unprecedented number of sequence changes relative to previous variants. In this review, we discuss how Omicron S protein structural features modulate host cell receptor binding, virus entry, and immune evasion and highlight how these structural features differentiate Omicron from previous variants. We also examine how key structural properties track across the still-evolving Omicron subvariants and the importance of continuing surveillance of the S protein sequence evolution over time.
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页数：13
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