The Road from AKI to CKD: Molecular Mechanisms and Therapeutic Targets of Ferroptosis

被引:40
|
作者
Guo, Runzhi [1 ,2 ,3 ,4 ]
Duan, Jiayu [1 ,2 ,3 ,4 ]
Pan, Shaokang [1 ,2 ,3 ,4 ]
Cheng, Fei [1 ,2 ,3 ,4 ]
Qiao, Yingjin [5 ]
Feng, Qi [1 ,2 ,3 ,4 ]
Liu, Dongwei [1 ,2 ,3 ,4 ]
Liu, Zhangsuo [1 ,2 ,3 ,4 ]
机构
[1] Zhengzhou Univ, Affiliated Hosp 1, Res Inst Nephrol, Zhengzhou 450052, Peoples R China
[2] Zhengzhou Univ, Affiliated Hosp 1, Tradit Chinese Med Integrated Dept Nephrol, Zhengzhou 450052, Peoples R China
[3] Henan Prov Res Ctr Kidney Dis, Zhengzhou 450052, Peoples R China
[4] Key Lab Precis Diag & Treatment Chron Kidney Dis H, Zhengzhou 450052, Peoples R China
[5] Zhengzhou Univ, Affiliated Hosp 1, Blood Purificat Ctr, Zhengzhou 450052, Peoples R China
基金
中国博士后科学基金; 中国国家自然科学基金;
关键词
ACUTE KIDNEY INJURY; NF-KAPPA-B; CELL-DEATH; IRON HOMEOSTASIS; GLUTATHIONE; PATHOPHYSIOLOGY; IDENTIFICATION; PEROXIDATION; NECROPTOSIS; METABOLISM;
D O I
10.1038/s41419-023-05969-9
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Acute kidney injury (AKI) is a prevalent pathological condition that is characterized by a precipitous decline in renal function. In recent years, a growing body of studies have demonstrated that renal maladaptation following AKI results in chronic kidney disease (CKD). Therefore, targeting the transition of AKI to CKD displays excellent therapeutic potential. However, the mechanism of AKI to CKD is mediated by multifactor, and there is still a lack of effective treatments. Ferroptosis, a novel nonapoptotic form of cell death, is believed to have a role in the AKI to CKD progression. In this study, we retrospectively examined the history and characteristics of ferroptosis, summarized ferroptosis's research progress in AKI and CKD, and discussed how ferroptosis participates in regulating the pathological mechanism in the progression of AKI to CKD. Furthermore, we highlighted the limitations of present research and projected the future evolution of ferroptosis. We hope this work will provide clues for further studies of ferroptosis in AKI to CKD and contribute to the study of effective therapeutic targets to prevent the progression of kidney diseases.
引用
收藏
页数:12
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