Risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food

被引:1
|
作者
Schrenk, Dieter
Bignami, Margherita
Bodin, Laurent
Chipman, James Kevin
del Mazo, Jesus
Grasl-Kraupp, Bettina
Hogstrand, Christer
Hoogenboom, Laurentius
Leblanc, Jean-Charles
Nebbia, Carlo Stefano
Ntzani, Evangelia
Petersen, Annette
Sand, Salomon
Schwerdtle, Tanja
Vleminckx, Christiane
Wallace, Heather
Falandysz, Jerzy
Hart, Andrew
Rose, Martin
Anastassiadou, Maria
Eskes, Chantra
Gergelova, Petra
Innocenti, Matteo
Rovesti, Elena
Whitty, Ben
Nielsen, Elsa
机构
关键词
feed; food; PCNs; Polychlorinated naphthalenes; risk assessment; POLYCYCLIC AROMATIC-HYDROCARBONS; DIOXIN-LIKE COMPOUNDS; DIBENZO-P-DIOXINS; POLYBROMINATED DIPHENYL ETHERS; SWEDISH HUMAN-MILK; CHLORINATED NAPHTHALENES; SPATIAL-DISTRIBUTION; TISSUE DISTRIBUTION; LAKE TROUT; 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TCDD;
D O I
10.2903/j.efsa.2024.8640
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
EFSA was asked for a scientific opinion on the risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food. The assessment focused on hexaCNs due to very limited data on other PCN congeners. For hexaCNs in feed, 217 analytical results were used to estimate dietary exposures for food-producing and non-food-producing animals; however, a risk characterisation could not be performed because none of the toxicological studies allowed identification of reference points. The oral repeated dose toxicity studies performed in rats with a hexaCN mixture containing all 10 hexaCNs indicated that the critical target was the haematological system. A BMDL20 of 0.05 mg/kg body weight (bw) per day was identified for a considerable decrease in the platelet count. For hexaCNs in food, 2317 analytical results were used to estimate dietary exposures across dietary surveys and age groups. The highest exposure ranged from 0.91 to 29.8 pg/kg bw per day in general population and from 220 to 559 pg/kg bw per day for breast-fed infants with the highest consumption of breast milk. Applying a margin of exposure (MOE) approach, the estimated MOEs for the high dietary exposures ranged from 1,700,000 to 55,000,000 for the general population and from 90,000 to 230,000 for breast-fed infants with the highest consumption of breast milk. These MOEs are far above the minimum MOE of 2000 that does not raise a health concern. Taking account of the uncertainties affecting the assessment, the Panel concluded with at least 99% certainty that dietary exposure to hexaCNs does not raise a health concern for any of the population groups considered. Due to major limitations in the available data, no assessment was possible for genotoxic effects or for health risks of PCNs other than hexaCNs.
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页数:131
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