In vitro biological activity of cobalt(II) complexes with salicylaldimine ligands in microbial and cancer cells

被引：0
|
作者：
Williem, Ereny S. [1 ]
Ibrahim, Ahmed B. M. [2 ]
Elkhalik, S. Abd [1 ]
Marek, Jaromir [3 ,4 ]
Abbas, S. M. [1 ]
机构：
[1] Beni Suef Univ, Fac Sci, Chem Dept, Bani Suwayf 62521, Egypt
[2] Assiut Univ, Fac Sci, Dept Chem, Assiut 71516, Egypt
[3] Masaryk Univ, Core Facil Biomol Interact & Crystallog, CEITEC MU, Kamenice 5, Brno 62500, Czech Republic
[4] Masaryk Univ, Fac Sci, Dept Chem, Kamenice 5, Brno 62500, Czech Republic
来源：
FUTURE MEDICINAL CHEMISTRY | 2023年 / 15卷 / 15期
关键词：
anionic ligands; breast cells; Candida albicans; Schiff bases; Staphylococcus aureus; tetrahedral; SCHIFF-BASE; CRYSTAL-STRUCTURE; METAL-COMPLEXES; COPPER-COMPLEXES; DNA CLEAVAGE; BINDING; SALEN; NI(II); CO(II); CYTOTOXICITY;
D O I：
10.4155/fmc-2023-0190
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Background: More studies using cobalt complexes as drugs are needed. Results: The drug action of two cobalt salicylaldimines was determined. The complexes and amphotericin B (20 mg/ml) inhibited Candida albicans at 9-15 and 21 mm. This concentration of both ligands inhibited Staphylococcus aureus at 10 mm and one ligand inhibited Escherichia coli at 9 mm, but the complexes and ampicillin inhibited four bacteria at 9-20 and 21-26 mm. The ligands were inactive against cancer and normal cells, but the complexes and doxorubicin provided IC50 values of 28.18-54.19 and 9.66 & mu;M against MCF-7 cells and 15.76-20.49 and 36.42 & mu;M against BHK cells. Conclusion: The ligands' activity was much improved by complexation, although they remained substandard.
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收藏
页码：1415 / 1426
页数：12
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