Cancer mortality in chrysotile miners and millers, Russian Federation: main results (Asbest Chrysotile Cohort-Study)

被引:0
|
作者
Schuez, Joachim [1 ,7 ]
Kovalevskiy, Evgeny [2 ,3 ]
Olsson, Ann [1 ]
Moissonnier, Monika [1 ]
Ostroumova, Evgenia [1 ]
Ferro, Gilles [1 ]
Feletto, Eleonora [1 ,4 ]
Schonfeld, Sara J. [1 ,5 ]
Byrnes, Graham [1 ]
Tskhomariia, Iraklii [2 ]
Straif, Kurt [1 ]
Morozova, Tatiana [3 ]
Kromhout, Hans [6 ]
Bukhtiyarov, Igor [2 ,3 ]
机构
[1] WHO, Int Agcy Res Canc, Lyon, France
[2] Fed State Budgetary Sci Inst, Izmerov Res Inst Occupat Hlth, Moscow, Russia
[3] IM Sechenov First Moscow State Med Univ, Sechenov Univ, Moscow, Russia
[4] Univ Sydney, Daffodil Ctr, Sydney, Australia
[5] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD USA
[6] Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands
[7] WHO, Environm & Lifestyle Epidemiol Branch, Int Agcy Res Canc, 25 Ave Tony Garnier, F-69366 Lyon 07, France
基金
美国国家卫生研究院;
关键词
POOLED ANALYSIS; LUNG-CANCER; EXPOSURE; DUST; FACTORIES;
D O I
10.1093/jnci/djad262
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background We investigated mortality in workers of the world's largest chrysotile mine and enrichment factories located in the town of Asbest, Russian Federation.Methods This historical cohort study included all workers employed for at least 1 year between 1975 and 2010 and follow-up until the end of 2015. Cumulative exposure to dust was estimated based on workers' complete occupational history linked to dust measurements systematically collected from the 1950s. Exposure to chrysotile fibers was estimated using dust-to-fiber conversion factors. Relative risks (RRs) and 95% confidence intervals (CIs) were estimated as mortality rate ratios in Poisson regression models.Results A total of 30 445 (32% women) workers accumulated 721 312 person-years at risk and 11 110 (36%) died. Of the workers, 54% had more than 30 years since their first exposure. We found an exposure-response between cumulative dust and lung cancer mortality in men. No clear association with dust exposure but a modest increase in the highest category of fiber exposure was seen for lung cancer in women. Mesothelioma mortality was increased (RR = 7.64, 95% CI = 1.18 to 49.5, to at least 80 fibers per cm3 years and RR = 4.56, 95% CI = 0.94 to 22.1, to at least 150 mg/m3 years [dust]), based on 13 deaths. For colorectal and stomach cancer, there were inconsistent associations. No associations were seen for laryngeal or ovarian cancer.Conclusion In this large-scale epidemiological study in the world's largest active asbestos mine, we confirmed an increased risk of mesothelioma with high fiber exposure and an increasing mortality for lung cancer in men with increasing dust exposure. Less clear-cut increased lung cancer mortality was seen in the women. Continued mortality follow-up is warranted.
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页数:10
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