Consider a pair of random vectors (X, Y) and the conditional expectation operator E[X|Y = y]. This work studies analytical properties of the conditional expectation by characterizing various derivative identities. The paper consists of two parts. In the first part of the paper, a general derivative identity for the conditional expectation is derived. Specifically, for the Markov chain U ? X ? Y, a compact expression for the Jacobian matrix of E[?(Y, U)|Y = y] for a smooth function ? is derived. In the second part of the paper, the main identity is specialized to the exponential family and two main applications are shown. First, it is demonstrated that, via various choices of the random vector U and function ?, one can recover and generalize several known identities (e.g., Tweedie's formula) and derive some new ones. For example, a new relationship between conditional expectations and conditional cumulants is established. Second, it is demonstrated how the derivative identities can be used to establish new lower bounds on the estimation error. More specifically, using one of the derivative identities in conjunction with a Poincare inequality, a new lower bound on the minimum mean squared error, which holds for all prior distributions on the input signal, is derived. The new lower bound is shown to be tight in the high-noise regime for the additive Gaussian noise setting.