Foegraecumoside O and P, a Pair of Triterpenoid Saponins with a 4/5/6 Fused Tricyclic Oleanane Carbon Skeleton from Lysimachia foenum-graecum Hance

被引：1

作者：

Dai, Lumei ^{[1
,2
]}

He, Shuang ^{[1
]}

Zhang, Bin ^{[1
]}

Wang, Hengshan ^{[1
]}

Wang, Yan ^{[1
,3
]}

Liang, Dong ^{[1
]}

机构：

[1] Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China

[2] Huanghuai Univ, Sch Biol & Food Engn, Zhumadian 463000, Peoples R China

[3] Univ Karachi, H E J Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan

来源：

MOLECULES | 2023年 / 28卷 / 13期

基金：

中国国家自然科学基金;

关键词：

Primulaceae; Lysimachia; Lysimachia foenum-graecum; triterpenoids; cytotoxicity; DRUG-RESISTANCE; CANCER;

D O I：

10.3390/molecules28135061

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lysimachia foenum-graecum Hance (Primulaceae) is a medicinal plant used for cold, pain, ascariasis, etc., in China. Triterpenoid saponins have been found to be the main components of this genus. In this work, a pair of oleanane-type triterpenoid saponins with an unprecedented 4/5/6 fused tricyclic skeleton, foegraecumoside O (1) and foegraecumoside P (2) were isolated from the butanol fraction of the aerial parts of L. foenum-graecum. Their structures were determined using chemical methods and extensive spectroscopic analyses, along with quantum chemical calculations. Compound 2 displayed moderate cytotoxicity against HepG2, MGC-803, T24, NCI-H460, A549, and A549/CDDP (drug-resistant lung-cancer cell line) with IC50 at 12.4-19.2 & mu;M in an MTT assay, comparing with the positive control doxorubicin, which had IC50 at 0.53-4.92 & mu;M, but was inactive for A549/CDDP. Furthermore, a possible biosynthetic pathway for forming compounds 1 and 2 was proposed.

引用

页数：12