Advances in the study of acetaminophen-induced liver injury

被引：11
|
作者：
Li, Xinghui [1 ]
Ni, Jiaqi [1 ,2 ,3 ]
Chen, Li [2 ,3 ]
机构：
[1] Sichuan Univ, West China Sch Pharm, Chengdu, Peoples R China
[2] Sichuan Univ, West China Univ Hosp 2, Evidence Based Pharm Ctr, Dept Pharm, Chengdu, Peoples R China
[3] Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Childr, Minist Educ, Chengdu, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2023年 / 14卷
关键词：
drug-induced liver injury; acetaminophen-induced liver injury; diagnosis; screening; prevention and management; INDUCED HEPATOTOXICITY; OXIDATIVE STRESS; IN-VIVO; DRUG; FAILURE; MANAGEMENT; DIAGNOSIS; ACTIVATION; INDUCTION; MICE;
D O I：
10.3389/fphar.2023.1239395
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Acetaminophen (APAP) overdose is a significant cause of drug-induced liver injury and acute liver failure. The diagnosis, screening, and management of APAP-induced liver injury (AILI) is challenging because of the complex mechanisms involved. Starting from the current studies on the mechanisms of AILI, this review focuses on novel findings in the field of diagnosis, screening, and management of AILI. It highlights the current issues that need to be addressed. This review is supposed to summarize the recent research progress and make recommendations for future research.
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页数：13
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