Plain language summary of the INCREASE study: inhaled treprostinil (Tyvaso) for the treatment of pulmonary hypertension due to interstitial lung disease

被引：2
|
作者：
West, Natalie [1 ,2 ]
Smoot, Karen [2 ]
Patzlaff, Natalie [1 ]
Miceli, Melissa [1 ]
Waxman, Aaron [3 ]
机构：
[1] United Therapeut Corp, 1040 Spring St, Silver Spring, MA 20910 USA
[2] Pulm Fibrosis Fdn, Chicago, IL 60611 USA
[3] Brigham & Womens Hosp, Boston, MA 02115 USA
来源：
FUTURE CARDIOLOGY | 2023年 / 19卷 / 05期
关键词：
interstitial lung disease; lay summary; plain language summary; pulmonary hypertension; treprostinil;
D O I：
10.2217/fca-2022-0108
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A total of 326 participants took part in the study. Half the participants took inhaled treprostinil and the other half took placebo. After 16 weeks, the INCREASE study showed that participants with PH-ILD who took inhaled treprostinil could walk around 31 meters (102 feet) further than the participants who took placebo. Participants taking inhaled treprostinil also had a decrease in NT-proBNP, which is a protein found in the blood. Lower NT-proBNP levels suggest that the heart is functioning better compared with higher levels. Participants taking inhaled treprostinil showed a decrease of NT-proBNP of 15% compared to a 46% increase in participants taking placebo. More participants taking placebo had worsening of their PH-ILD (33%) compared to participants taking inhaled treprostinil (& SIM;23%). The most common side effects reported in the study were cough, headache, and shortness of breath.
引用
收藏
页码：229 / 239
页数：11
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